Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7056950 | 1.00 | LMNA (0.52) | LMNAMAPK1MAPTAOC3MEN1 | |
| SCHEMBL295743 | 1.00 | LMNA (0.52) | LMNAMAPK1MAPTAOC3MEN1 | |
| SCHEMBL5162907 | 0.83 | LMNA (0.42) | LMNAMAPK1MAPTMEN1KMT2A | |
| SCHEMBL5929629 | 0.83 | LMNA (0.42) | LMNAMAPK1MAPTMEN1KMT2A | |
| SCHEMBL27559595 | 0.82 | LMNA (0.50) | LMNAMAPK1MAPTADRA2AADRA2C | |
| SCHEMBL5929551 | 0.81 | SMN1; SMN2 (0.50) | LMNAKMT2AKDM4ECYP2D6ALDH1A1 | |
| SCHEMBL5160712 | 0.81 | SMN1; SMN2 (0.50) | LMNAKMT2AKDM4ECYP2D6ALDH1A1 | |
| SCHEMBL10644619 | 0.80 | AKR1C3 (0.51) | — | |
| SCHEMBL20291832 | 0.80 | MME (0.56) | LMNAMEN1KMT2ACYP2D6SRC | |
| SCHEMBL20876113 | 0.80 | TDP1 (0.50) | LMNAMAPK1MAPTCYP2D6SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871782-B1 | DIPHOSPHINES AND METAL COMPLEXES | UMICORE AG & CO KG (DE) | 2012-02-29 | — | — | EP | disclosed |