Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | CA4 | P22748 | 3/20 | 0.37 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL27768242 | 0.78 | ALDH1A1 (0.60) | ALDH1A1TSHRTP53 | |
| Potassium Ion SCHEMBL8115754 | 0.72 | CA4 (0.43) | CA4FAHD1 | |
| Potassium Ion SCHEMBL8854854 | 0.72 | — | — | |
| SCHEMBL27750845 | 0.71 | — | — | |
| SCHEMBL9683824 | 0.71 | — | — | |
| SCHEMBL4158386 | 0.71 | ALDH1A1 (0.90) | ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL4078190 | 0.71 | — | — | |
| Phosphoric Acid SCHEMBL15389164 | 0.71 | ALDH1A1 (0.60) | ALDH1A1TSHR | |
| Bicarbonate SCHEMBL8533360 | 0.71 | CA4 (0.60) | CA4FAHD1 | |
| Bicarbonate SCHEMBL22476039 | 0.71 | CA4 (0.46) | TSHRCA4FAHD1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0852500-A4 | MODIFIED ETHER GLYCEROGLYCOLIPIDS | ZENEUS PHARMA LTD (GB) | 2007-11-14 | — | — | EP | disclosed |
| US-6573246-B1 | Anticancer agents | THE LIPOSOME COMPANY, INC. | 2003-06-03 | — | — | US | disclosed |
| US-6153736-A | ANTICANCER AGENTS | THE LIPOSOME COMPANY, INC. (US) | 2000-11-28 | — | — | US | disclosed |
| EP-0852500-A1 | MODIFIED ETHER GLYCEROGLYCOLIPIDS | THE LIPOSOME COMPANY, INC. (US) | 1998-07-15 | — | — | EP | disclosed |
| WO-1997011707-A1 | MODIFIED ETHER GLYCEROGLYCOLIPIDS | THE LIPOSOME COMPANY, INC. (US) | 1997-04-03 | — | — | WO | disclosed |