Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5162585 | 0.94 | LMNA (0.48) | LMNATSHRMAPK1MEN1KMT2A | |
| SCHEMBL5162667 | 0.90 | ALDH1A1 (0.52) | LMNATSHRMAPK1MEN1KMT2A | |
| SCHEMBL5159110 | 0.80 | HDAC1 (0.52) | MEN1KMT2AHDAC1HDAC3HDAC2 | |
| SCHEMBL4894790 | 0.74 | HDAC3 (0.54) | HDAC1HDAC3HDAC2HDAC10HDAC6 | |
| SCHEMBL3812243 | 0.72 | HDAC1 (0.64) | HDAC1HDAC3HDAC2HDAC10HDAC6 | |
| SCHEMBL1521002 | 0.72 | RAB9A (0.71) | MEN1KMT2AHDAC1HDAC3HDAC2 | |
| SCHEMBL4261798 | 0.71 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC10HDAC6 | |
| SCHEMBL4261801 | 0.71 | HDAC1 (0.69) | HDAC1HDAC3HDAC2HDAC10HDAC6 | |
| SCHEMBL5178132 | 0.71 | HDAC3 (0.53) | HDAC1HDAC3HDAC2HDAC10HDAC6 | |
| SCHEMBL4714063 | 0.71 | HDAC1 (0.66) | HDAC1HDAC3HDAC2HDAC10HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758847-A1 | INHIBITORS OF HISTONE DEACETYLASE | Cancer Research Technology Limited (GB) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005121073-A1 | INHIBITORS OF HISTONE DEACETYLASE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2005-12-22 | — | — | WO | disclosed |