Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 7/20 | 0.55 |
| ▸ | ITGA4 | P13612 | 7/20 | 0.55 |
| ▸ | ITGB7 | P26010 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27511850 | 0.88 | ITGB1 (0.61) | ITGB1ITGA4ITGB7PTGS2HSD17B10 | |
| SCHEMBL27511849 | 0.88 | ITGB1 (0.61) | ITGB1ITGA4ITGB7PTGS2HSD17B10 | |
| SCHEMBL5163064 | 0.84 | ITGA4 (0.39) | ITGB1ITGA4ITGB7ALDH1A1PTGS2 | |
| Hydrochloric Acid SCHEMBL5165900 | 0.83 | ALDH1A1 (0.41) | ITGB1ITGA4ITGB7ALDH1A1PTGS2 | |
| SCHEMBL5162201 | 0.83 | ITGB1 (0.55) | ITGB1ITGA4ITGB7ALDH1A1PTGS2 | |
| SCHEMBL5162949 | 0.79 | ITGA4 (0.59) | ITGB1ITGA4ITGB7ALDH1A1TSHR | |
| SCHEMBL5159923 | 0.78 | ITGA4 (0.84) | ITGB1ITGA4ITGB7 | |
| SCHEMBL27488188 | 0.76 | DPP4 (0.42) | ITGA4ITGB7ALDH1A1PTGS2 | |
| SCHEMBL27488187 | 0.76 | DPP4 (0.42) | ITGA4ITGB7ALDH1A1PTGS2 | |
| SCHEMBL22996698 | 0.75 | ITGB1 (0.45) | ITGB1ITGA4ITGB7ALDH1A1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237878-B1 | 4-PYRIMIDINYL-N-ACYL-L-PHENYLALANINES | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |
| EP-1237878-A2 | 4-PYRIMIDINYL-N-ACYL-L-PHENYLALANINES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6380387-B1 | ANTIINFLAMMATORY AGENTS, ANTIASTHMATICS | HOFFMANN-LA ROCHE INC. | 2002-04-30 | — | — | US | disclosed |
| WO-2001042225-A2 | 4-PYRIMIDINYL-N-ACYL-L-PHENYLALANINES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-14 | — | — | WO | disclosed |