Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5713447 | 0.89 | HRH3 (0.37) | HRH3MTNR1B | |
| SCHEMBL5713471 | 0.84 | HRH3 (0.39) | HRH3ACACB | |
| SCHEMBL5551732 | 0.82 | MTNR1B (0.50) | MTNR1B | |
| SCHEMBL5713465 | 0.82 | HRH3 (0.39) | HRH3ADRB3ADRB1GHSR | |
| SCHEMBL5161059 | 0.82 | OPRM1 (0.41) | HRH3 | |
| SCHEMBL5713479 | 0.80 | HRH3 (0.46) | HRH3 | |
| SCHEMBL5158952 | 0.80 | HRH3 (0.43) | HRH3MTNR1B | |
| SCHEMBL6223629 | 0.79 | HRH3 (0.54) | HRH3 | |
| SCHEMBL5165139 | 0.79 | GRIN1 (0.54) | HRH3GHSR | |
| SCHEMBL2124647 | 0.79 | ESR1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735299-A1 | TERTRAHYDROBENZAZEPINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005097778-A1 | TETRAHYDROBENZAZEPINES AS HISTAMINE H3 RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2005-10-20 | — | — | WO | disclosed |