Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 5/20 | 0.42 |
| ▸ | MMP3 | P08254 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 5/20 | 0.37 |
| ▸ | MMP9 | P14780 | 4/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 5/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5160889 | 0.93 | MMP1 (0.45) | MMP8MMP3MMP2MMP9MMP1 | |
| SCHEMBL5188709 | 0.93 | MMP1 (0.45) | MMP8MMP3MMP2MMP9MMP1 | |
| SCHEMBL5164149 | 0.93 | MMP1 (0.45) | MMP8MMP3MMP2MMP9MMP1 | |
| SCHEMBL5163447 | 0.89 | MMP3 (0.41) | MMP8MMP3POLBMMP2MMP9 | |
| SCHEMBL5441525 | 0.89 | PSEN1 (0.38) | MMP8MMP3POLBPSEN1PSEN2 | |
| SCHEMBL5160057 | 0.86 | MMP1 (0.46) | MMP3MMP2MMP9MMP1HCRTR1 | |
| SCHEMBL5164121 | 0.86 | MMP1 (0.46) | MMP3MMP2MMP9MMP1HCRTR1 | |
| SCHEMBL5161051 | 0.86 | MMP1 (0.46) | MMP3MMP2MMP9MMP1HCRTR1 | |
| SCHEMBL5163129 | 0.85 | MMP3 (0.41) | MMP8MMP3POLBMMP2MMP9 | |
| SCHEMBL5163203 | 0.84 | MMP1 (0.46) | MMP8MMP3MMP2MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763516-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | Sanofi-Aventis Deutschland GmbH (DE) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002763-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-01-12 | — | — | WO | disclosed |