Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 15/20 | 0.46 |
| ▸ | MMP3 | P08254 | 11/20 | 0.46 |
| ▸ | MMP7 | P09237 | 10/20 | 0.46 |
| ▸ | MMP13 | P45452 | 9/20 | 0.46 |
| ▸ | MMP9 | P14780 | 7/20 | 0.46 |
| ▸ | MMP2 | P08253 | 6/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.46 |
| ▸ | MMP14 | P50281 | 2/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5161051 | 0.92 | MMP1 (0.46) | MMP1MMP3MMP7MMP13MMP9 | |
| SCHEMBL5160057 | 0.92 | MMP1 (0.46) | MMP1MMP3MMP7MMP13MMP9 | |
| SCHEMBL5164121 | 0.92 | MMP1 (0.46) | MMP1MMP3MMP7MMP13MMP9 | |
| SCHEMBL5164149 | 0.91 | MMP1 (0.45) | MMP1MMP3MMP7MMP13MMP9 | |
| SCHEMBL5188709 | 0.91 | MMP1 (0.45) | MMP1MMP3MMP7MMP13MMP9 | |
| SCHEMBL5160889 | 0.91 | MMP1 (0.45) | MMP1MMP3MMP7MMP13MMP9 | |
| SCHEMBL5160964 | 0.90 | MMP1 (0.45) | MMP1MMP3MMP7MMP13MMP9 | |
| SCHEMBL5441314 | 0.90 | MMP1 (0.41) | MMP1MMP3MMP7MMP13MMP9 | |
| SCHEMBL14427241 | 0.86 | MMP1 (0.51) | MMP1MMP3MMP7MMP13MMP9 | |
| SCHEMBL5162221 | 0.84 | MMP8 (0.42) | MMP1MMP3MMP7MMP9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763516-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | Sanofi-Aventis Deutschland GmbH (DE) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002763-A2 | SUBSTITUTED TETRAHYDROISOCHINOLINES USED IN THE FORM OF MMP INHIBITORS, METHOD FOR THE PRODUCTION AND USE THEREOF IN THE FORM OF DRAGS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-01-12 | — | — | WO | disclosed |