Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 7/20 | 0.52 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.46 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | CCKBR | P32239 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11586019 | 0.80 | KCNN4 (0.53) | KCNN4KCNE1KCNQ1ALDH1A1TSHR | |
| SCHEMBL2243767 | 0.80 | KCNN4 (0.53) | KCNN4KCNE1KCNQ1ALDH1A1TSHR | |
| SCHEMBL9548120 | 0.78 | ALDH1A1 (0.58) | KCNN4ALDH1A1TSHRKIF11PTPN1 | |
| SCHEMBL7777113 | 0.77 | KCNN4 (0.44) | KCNN4KCNE1KCNQ1ALDH1A1CCR6 | |
| SCHEMBL9562078 | 0.76 | ALDH1A1 (0.37) | KCNN4KCNE1KCNQ1ALDH1A1TSHR | |
| SCHEMBL6489440 | 0.75 | KCNN4 (0.42) | KCNN4KCNE1KCNQ1ALDH1A1CCR6 | |
| SCHEMBL3406219 | 0.74 | KCNN4 (0.47) | KCNN4KCNE1KCNQ1ALDH1A1TSHR | |
| SCHEMBL30293723 | 0.74 | KCNN4 (0.58) | KCNN4KCNE1KCNQ1MLNRNR1I2 | |
| SCHEMBL9670139 | 0.74 | KCNN4 (0.47) | KCNN4KCNE1KCNQ1ALDH1A1TSHR | |
| SCHEMBL1443904 | 0.74 | KCNN4 (0.58) | KCNN4KCNE1KCNQ1MLNRNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758874-A1 | SUBSTITUTED THIAZOLEACETIC ACIDS AS CRTH2 LIGANDS | 7TM Pharma A/S (DK) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005116001-A1 | SUBSTITUTED THIAZOLEACETIC AS CRTH2 LIGANDS | 7TM PHARMA A/S (DK) | 2005-12-08 | — | — | WO | disclosed |