Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carboxynaphthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | RAC1 | P63000 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6105720 | 0.82 | KDM4E (0.47) | NPC1RAB9AKDM4EKMT2AMAPT | |
| Resorcinol SCHEMBL11347942 | 0.78 | KDM4E (0.45) | NPC1RAB9AKDM4EKMT2AMAPT | |
| Carboxynaphthol SCHEMBL8742000 | 0.74 | LDHA (0.55) | LDHANPC1RAB9AKDM4EKMT2A | |
| Carboxynaphthol SCHEMBL5162354 | 0.74 | LDHA (0.55) | LDHANPC1RAB9AKDM4EKMT2A | |
| Carboxynaphthol SCHEMBL3770341 | 0.73 | LDHA (1.00) | LDHAKDM4EKMT2AMAPTALDH1A1 | |
| Carboxynaphthol SCHEMBL2099330 | 0.73 | LDHA (1.00) | LDHAKDM4EKMT2AMAPTALDH1A1 | |
| Carboxynaphthol SCHEMBL25244 | 0.73 | LDHA (1.00) | LDHAKDM4EKMT2AMAPTALDH1A1 | |
| SCHEMBL6269823 | 0.72 | KDM4E (0.49) | KDM4EMAPTALDH1A1LMNA | |
| SCHEMBL4578678 | 0.72 | NPC1 (0.51) | LDHANPC1RAB9ARAC1KDM4E | |
| SCHEMBL3541446 | 0.72 | NPC1 (0.69) | LDHANPC1RAB9ARAC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1382385-B1 | Microcapsule and process for manufacturing the same | FUJIFILM CORP (JP) | 2007-03-21 | — | — | EP | disclosed |
| US-20070047038-A1 | Hologram recording method, hologram recording material, optical recording medium | FUJI PHOTO FILM CO., LTD. | 2007-03-01 | — | — | US | disclosed |
| US-20070048666-A1 | Two-photon recording method, two-photon absorption recording material, two-photon absorption recording-reproduction method and optical recoding medium | FUJI PHOTO FILM CO., LTD. | 2007-03-01 | — | — | US | disclosed |
| US-7022823-B2 | Diazonium salt, its synthesizing method and recording material | FUJI PHOTO FILM CO., LTD. (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20050260518-A1 | Heat sensitive recording material and microcapsule | FUJI PHOTO FILM CO., LTD. | 2005-11-24 | — | — | US | disclosed |
| EP-1598206-A2 | Heat sensitive recording material and microcapsule | FUJI PHOTO FILM CO., LTD. (JP) | 2005-11-23 | — | — | EP | disclosed |
| CN-1221853-C | Diazo copying material, diazo copying method and diazo copied image forming device | RICOH KK (JP) | 2005-10-05 | — | — | CN | disclosed |
| US-6881810-B2 | Microcapsule and process for manufacturing the same | FUJI PHOTO FILM CO., LTD. (JP) | 2005-04-19 | — | — | US | disclosed |
| US-6875551-B2 | Heat-sensitive recording material | FUJI PHOTO FILM CO., LTD. (JP) | 2005-04-05 | — | — | US | disclosed |
| US-20040161694-A1 | Heat-sensitive recording material | FUJI PHOTO FILM CO., LTD. | 2004-08-19 | — | — | US | disclosed |
| US-20040121155-A1 | Microcapsule and process for manufacturing the same | FUJI PHOTO FILM CO., LTD. (JP) | 2004-06-24 | — | — | US | disclosed |
| US-6727203-B2 | PARTICLE DIAMETERS ARE SMALL AND WHOSE PARTICLE DIAMETER DISTRIBUTION IS LIMITED, | FUJI PHOTO FILM CO., LTD. (JP) | 2004-04-27 | — | — | US | disclosed |
| US-20040039180-A1 | Diazonium salt, its synthesizing method and recording material | FUJI PHOTO FILM CO., LTD. | 2004-02-26 | — | — | US | disclosed |
| EP-1382385-A1 | Microcapsule and process for manufacturing the same | FUJI PHOTO FILM CO., LTD. (JP) | 2004-01-21 | — | — | EP | disclosed |
| US-20020142915-A1 | Method for producing microcapsules and heat-sensitive recording material | FUJI PHOTO FILM CO., LTD. | 2002-10-03 | — | — | US | disclosed |
| CN-1330286-A | Diazo copying material, diazo copying method and diazo copied image forming device | RICOH KK (JP) | 2002-01-09 | — | — | CN | disclosed |
| US-6060206-A | Photo- and heat-sensitive recording material and colorant produced from the material | FUJI PHOTO FILM CO., LTD. (JP) | 2000-05-09 | — | — | US | disclosed |
| EP-0352122-A2 | Heat development type diazo copying material | FUJI PHOTO FILM CO., LTD. (JP) | 1990-01-24 | — | — | EP | disclosed |
| US-4644376-A | Heat-sensitive recording material | FUJI PHOTO FILM CO., LTD. (JP) | 1987-02-17 | — | — | US | disclosed |
| US-4419432-A | CAPROLACTAM, CAPRYLOLACTAM, OR AZACYCLOOCTAN-ONE STABILIZER | KEUFFEL & ESSER COMPANY (US) | 1983-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040039180-A1 | Diazonium salt, its synthesizing method and recording material | CACNA1E, HCN2, HCN1 | LDHA 3614/4885NPC1 2658/4885RAB9A 990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.