Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | ATF4 | P18848 | 3/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | ADIPOR2 | Q86V24 | 1/20 | 0.34 |
| ▸ | ADIPOR1 | Q96A54 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2976658 | 0.84 | MEN1 (0.45) | PPARGPPARALMNASIGMAR1MEN1 | |
| SCHEMBL2972810 | 0.84 | ATF4 (0.55) | ATF4MCHR1POLBUSP2LMNA | |
| SCHEMBL2989619 | 0.81 | KMT2A (0.48) | PPARGPPARAPOLBLMNAMEN1 | |
| SCHEMBL2989096 | 0.81 | ATF4 (0.58) | ATF4LMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL2987754 | 0.81 | POLB (0.50) | POLBUSP2LMNASIGMAR1ADIPOR2 | |
| SCHEMBL2982908 | 0.78 | MCHR1 (0.50) | ATF4MCHR1POLBLMNASIGMAR1 | |
| SCHEMBL2984841 | 0.78 | LMNA (0.48) | ATF4POLBLMNAMEN1ALDH1A1 | |
| SCHEMBL2987483 | 0.77 | ATF4 (0.61) | ATF4MCHR1POLBUSP2LMNA | |
| SCHEMBL5162540 | 0.77 | MCHR1 (0.46) | MCHR1POLBSIGMAR1 | |
| SCHEMBL2981298 | 0.77 | ATF4 (0.56) | ATF4MCHR1POLBLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747191-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES WITH A CHAIN EXTENSION | Grünenthal GmbH (DE) | 2007-01-31 | — | — | EP | disclosed |
| WO-2005110975-A1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES WITH A CHAIN EXTENSION | Grünenthal GmbH (DE) | 2005-11-24 | — | — | WO | disclosed |