⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3351759 | 0.83 | — | — | |
| SCHEMBL4849399 | 0.80 | — | — | |
| SCHEMBL4854427 | 0.80 | — | — | |
| SCHEMBL10386372 | 0.80 | — | — | |
| SCHEMBL5610978 | 0.80 | ALDH1A1 (0.38) | — | |
| SCHEMBL12964992 | 0.77 | — | — | |
| SCHEMBL28610373 | 0.77 | ALDH1A1 (0.36) | — | |
| SCHEMBL16148608 | 0.75 | — | — | |
| Trifluoroacetic Acid SCHEMBL30286957 | 0.75 | — | — | |
| SCHEMBL4850796 | 0.74 | THRB (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017162663-A1 | PRODRUGS OF CYTOTOXIC ACTIVE AGENTS HAVING ENZYMATICALLY CLEAVABLE GROUPS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-28 | — | — | WO | disclosed |
| EP-2320886-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORP (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-3078373-A1 | 2-ACYLAMINOPROPANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITOR | Genzyme Corporation (US) | 2016-10-12 | — | — | EP | disclosed |
| WO-2016033025-A1 | MOLECULES HAVING CERTAIN PESTICIDAL UTILITIES, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES RELATED THERETO | DOW AGROSCIENCES LLC (US) | 2016-03-03 | — | — | WO | disclosed |
| WO-2014134426-A1 | USE OF PYRAZOLOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PI3Kδ RELATED DISORDERS | INCYTE CORPORATION (US) | 2014-09-04 | — | — | WO | disclosed |
| EP-1009726-B1 | FLUORINATION OF PROTEINS AND PEPTIDES FOR F-18 POSITRON EMISSION TOMOGRAPHY | IMMUNOMEDICS INC (US) | 2007-02-14 | — | — | EP | disclosed |
| US-6953567-B2 | Fluorination of proteins and peptides for F-18 positron emission tomography | IMMUNOMEDICS, INC. (US) | 2005-10-11 | — | — | US | disclosed |
| US-20020119096-A1 | Fluorination of proteins and peptides for F-18 positron emission tomography | IMMUNOMEDICS, INC. | 2002-08-29 | — | — | US | disclosed |
| US-6358489-B1 | REACTING PEPTIDE COMPRISING A FREE THIOL GROUP WITH A F-18 FLUORINATED ALKENE, WHEREIN AT LEAST ONE OF THE TWO DOUBLE-BONDED CARBON ATOMS BEARS LEAVING GROUP SELECTED FROM IODIDE, BROMIDE, CHLORIDE, AZIDE, TOSYLATE, MESYLATE, NOSYLATE | IMMUNOMEDICS, INC. | 2002-03-19 | — | — | US | disclosed |
| US-6187284-B1 | REACTING A PEPTIDE COMPRISING A FREE THIOL GROUP WITH AN 18 F-BOUND LABELLING REAGENT WHICH ALSO HAS A GROUP THAT IS REACTIVE WITH THIOLS. | IMMUNOMEDICS, INC. | 2001-02-13 | — | — | US | disclosed |
| EP-1009726-A1 | FLUORINATION OF PROTEINS AND PEPTIDES FOR F-18 POSITRON EMISSION TOMOGRAPHY | Immunomedics, Inc. (US) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999011590-A1 | FLUORINATION OF PROTEINS AND PEPTIDES FOR F-18 POSITRON EMISSION TOMOGRAPHY | IMMUNOMEDICS, INC. (US) | 1999-03-11 | — | — | WO | disclosed |