Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 18/20 | 0.41 |
| ▸ | CA2 | P00918 | 18/20 | 0.41 |
| ▸ | CA9 | Q16790 | 8/20 | 0.39 |
| ▸ | CA12 | O43570 | 7/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 3/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5161486 | 0.82 | P2RX4 (0.40) | CA1CA2CA9CA12F10 | |
| SCHEMBL5722111 | 0.81 | KMT2A (0.56) | CA1CA2CA9CA12CA7 | |
| SCHEMBL16861415 | 0.78 | CA12 (0.56) | CA1CA2CA9CA12CA7 | |
| SCHEMBL7737219 | 0.77 | CA1 (0.46) | CA1CA2CA9CA12 | |
| SCHEMBL8741155 | 0.76 | TSHR (0.43) | — | |
| SCHEMBL11427182 | 0.76 | CNR1 (0.42) | CA1CA2CA9CA12CA7 | |
| SCHEMBL13785813 | 0.75 | HSD17B10 (0.37) | — | |
| SCHEMBL10955222 | 0.74 | GABRP (0.41) | F10 | |
| SCHEMBL4619724 | 0.73 | CA1 (0.35) | CA1CA2CA9CA12CA7 | |
| SCHEMBL29839131 | 0.72 | LMNA (0.45) | CA1CA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756098-A2 | 2-SUBSTITUTED-4-HETEROARYL-PYRIMIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | Cyclacel Limited (GB) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005116025-A2 | 2-SUBSTITUTED-4-HETEROARYL-PYRIMIDINES USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | CYCLACEL LIMITED (GB) | 2005-12-08 | — | — | WO | disclosed |