Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 7/20 | 0.50 |
| ▸ | ITGA4 | P13612 | 7/20 | 0.50 |
| ▸ | ITGB7 | P26010 | 7/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | MC5R | P33032 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 4/20 | 0.40 |
| ▸ | YAP1 | P46937 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163361 | 0.93 | ITGA4 (0.55) | ITGB1ITGA4ITGB7KMT2ALMNA | |
| SCHEMBL20781286 | 0.83 | KMT2A (0.51) | MEN1KMT2ALMNANPSR1MC4R | |
| SCHEMBL18609373 | 0.82 | ALDH1A1 (0.55) | MEN1KMT2ALMNANPSR1MC4R | |
| SCHEMBL18577421 | 0.82 | ALDH1A1 (0.55) | MEN1KMT2ALMNANPSR1MC4R | |
| SCHEMBL18577417 | 0.82 | ALDH1A1 (0.55) | MEN1KMT2ALMNANPSR1MC4R | |
| SCHEMBL18577419 | 0.82 | ALDH1A1 (0.55) | MEN1KMT2ALMNANPSR1MC4R | |
| SCHEMBL15136783 | 0.82 | ITGA4 (0.55) | ITGB1ITGA4ITGB7 | |
| SCHEMBL5163463 | 0.82 | ITGA4 (0.55) | ITGB1ITGA4ITGB7 | |
| SCHEMBL28067688 | 0.82 | ACE (0.56) | MEN1KMT2ARENCMA1YAP1 | |
| SCHEMBL28067687 | 0.82 | ACE (0.56) | MEN1KMT2ARENCMA1YAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237878-B1 | 4-PYRIMIDINYL-N-ACYL-L-PHENYLALANINES | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |
| EP-1237878-A2 | 4-PYRIMIDINYL-N-ACYL-L-PHENYLALANINES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6380387-B1 | ANTIINFLAMMATORY AGENTS, ANTIASTHMATICS | HOFFMANN-LA ROCHE INC. | 2002-04-30 | — | — | US | disclosed |
| WO-2001042225-A2 | 4-PYRIMIDINYL-N-ACYL-L-PHENYLALANINES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-14 | — | — | WO | disclosed |