Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 11/20 | 0.55 |
| ▸ | ITGB7 | P26010 | 11/20 | 0.55 |
| ▸ | ITGB1 | P05556 | 10/20 | 0.55 |
| ▸ | CMA1 | P23946 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5162831 | 0.93 | ITGB1 (0.50) | ITGA4ITGB7ITGB1CMA1KMT2A | |
| SCHEMBL3825215 | 0.82 | CMA1 (0.63) | CMA1KMT2AMAPK1 | |
| SCHEMBL3165695 | 0.82 | CMA1 (0.63) | CMA1KMT2AMAPK1 | |
| SCHEMBL21748404 | 0.82 | CMA1 (0.63) | CMA1KMT2AMAPK1 | |
| SCHEMBL3165688 | 0.82 | CMA1 (0.63) | CMA1KMT2AMAPK1 | |
| SCHEMBL5689963 | 0.82 | CMA1 (0.54) | CMA1KMT2AMAPK1LMNANPSR1 | |
| SCHEMBL5164143 | 0.82 | ITGA4 (0.64) | ITGA4ITGB7ITGB1 | |
| SCHEMBL5689518 | 0.80 | CMA1 (0.53) | CMA1KMT2AMAPK1LMNANPSR1 | |
| SCHEMBL3824430 | 0.80 | CMA1 (0.52) | CMA1KMT2AMAPK1 | |
| SCHEMBL30152222 | 0.79 | CMA1 (0.59) | CMA1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237878-B1 | 4-PYRIMIDINYL-N-ACYL-L-PHENYLALANINES | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |
| EP-1237878-B1 | 4-PYRIMIDINYL-N-ACYL-L-PHENYLALANINES | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |
| EP-1237878-A2 | 4-PYRIMIDINYL-N-ACYL-L-PHENYLALANINES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6380387-B1 | ANTIINFLAMMATORY AGENTS, ANTIASTHMATICS | HOFFMANN-LA ROCHE INC. | 2002-04-30 | — | — | US | disclosed |
| WO-2001042225-A2 | 4-PYRIMIDINYL-N-ACYL-L-PHENYLALANINES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-14 | — | — | WO | disclosed |