Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BID | P55957 | 7/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 7/20 | 0.59 |
| ▸ | BCL2L1 | Q07817 | 6/20 | 0.59 |
| ▸ | BAK1 | Q16611 | 6/20 | 0.59 |
| ▸ | KAT8 | Q9H7Z6 | 3/20 | 0.59 |
| ▸ | PPARA | Q07869 | 3/20 | 0.59 |
| ▸ | PPARG | P37231 | 2/20 | 0.59 |
| ▸ | EP300 | Q09472 | 2/20 | 0.59 |
| ▸ | KAT5 | Q92993 | 2/20 | 0.59 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.59 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.59 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.52 |
| ▸ | F7 | P08709 | 3/20 | 0.50 |
| ▸ | F3 | P13726 | 3/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9700156 | 0.91 | BID (0.73) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL2129140 | 0.88 | BID (0.76) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL31319546 | 0.88 | BID (0.53) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL5164770 | 0.88 | BID (0.53) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL1355661 | 0.88 | BID (0.53) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL20505599 | 0.87 | BID (0.51) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL5163919 | 0.87 | BID (0.51) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL10489825 | 0.87 | BID (0.51) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL423306 | 0.84 | GABRA1 (0.54) | BIDMCL1BCL2L1BAK1KAT8 | |
| SCHEMBL25171586 | 0.84 | FOLH1 (0.71) | BIDMCL1BCL2L1BAK1KAT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237878-B1 | 4-PYRIMIDINYL-N-ACYL-L-PHENYLALANINES | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |
| EP-1237878-A2 | 4-PYRIMIDINYL-N-ACYL-L-PHENYLALANINES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-11 | — | — | EP | disclosed |
| US-6380387-B1 | ANTIINFLAMMATORY AGENTS, ANTIASTHMATICS | HOFFMANN-LA ROCHE INC. | 2002-04-30 | — | — | US | disclosed |
| WO-2001042225-A2 | 4-PYRIMIDINYL-N-ACYL-L-PHENYLALANINES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-14 | — | — | WO | disclosed |
| EP-1005445-A1 | N-ALKANOYLPHENYLALANINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-07 | — | — | EP | disclosed |
| WO-1999010312-A1 | N-ALKANOYLPHENYLALANINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-03-04 | — | — | WO | disclosed |