SCHEMBL5164770

SCHEMBL5164770

CCCc1cccc(C)c1C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BID P55957 6/20 0.53
MCL1 Q07820 6/20 0.53
BCL2L1 Q07817 5/20 0.53
BAK1 Q16611 5/20 0.53
KAT8 Q9H7Z6 3/20 0.53
PPARA Q07869 3/20 0.53
PPARG P37231 2/20 0.53
EP300 Q09472 2/20 0.53
KAT5 Q92993 2/20 0.53
SAE1 Q9UBE0 2/20 0.53
KAT2A Q92830 1/20 0.53
KAT2B Q92831 1/20 0.53
ITGB1 P05556 1/20 0.46
ITGA4 P13612 1/20 0.46
PTPN1 P18031 1/20 0.46
PTPN11 Q06124 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
MMP2 P08253 2/20 0.46
F7 P08709 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5162912 0.88 BID (0.59) BIDMCL1BCL2L1BAK1KAT8
SCHEMBL28201594 0.88 BID (0.60) BIDMCL1BCL2L1BAK1KAT8
SCHEMBL9342117 0.88 BID (0.69) BIDMCL1BCL2L1BAK1KAT8
SCHEMBL424866 0.86 L3MBTL1 (0.50) BIDMCL1BCL2L1BAK1KAT8
SCHEMBL16250350 0.86 BID (0.72) BIDMCL1BCL2L1BAK1KAT8
SCHEMBL7420497 0.84 ITGB1 (0.43) BIDMCL1BCL2L1BAK1KAT8
SCHEMBL8096271 0.84 ITGB1 (0.43) BIDMCL1BCL2L1BAK1KAT8
SCHEMBL30080957 0.83 IAPP (0.55) BIDMCL1BCL2L1BAK1KAT8
SCHEMBL28181875 0.83 IAPP (0.55) BIDMCL1BCL2L1BAK1KAT8
SCHEMBL14312370 0.82 BID (0.54) BIDMCL1BCL2L1BAK1KAT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1237878-B1 4-PYRIMIDINYL-N-ACYL-L-PHENYLALANINES HOFFMANN LA ROCHE (CH) 2007-03-21 EP disclosed
EP-1005445-B1 N-ALKANOYLPHENYLALANINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2004-05-26 EP disclosed
EP-1403247-A1 N-Alkanoylphenylalanine derivatives F.HOFFMANN-LA ROCHE AG (CH) 2004-03-31 EP disclosed
EP-1244625-A1 4-PYRIDINYL-N-ACYL-L-PHENYLALANINES F. HOFFMANN-LA ROCHE AG (CH) 2002-10-02 EP disclosed
EP-1237878-A2 4-PYRIMIDINYL-N-ACYL-L-PHENYLALANINES F. HOFFMANN-LA ROCHE AG (CH) 2002-09-11 EP disclosed
US-6380387-B1 ANTIINFLAMMATORY AGENTS, ANTIASTHMATICS HOFFMANN-LA ROCHE INC. 2002-04-30 US disclosed
WO-2001042225-A2 4-PYRIMIDINYL-N-ACYL-L-PHENYLALANINES F. HOFFMANN-LA ROCHE AG (CH) 2001-06-14 WO disclosed
WO-2001042215-A1 4-PYRIDINYL-N-ACYL-L-PHENYLALANINES F. HOFFMANN-LA ROCHE AG (CH) 2001-06-14 WO disclosed
US-6229011-B1 BINDING INHIBITORS BETWEEN VASCULAR ADHESION MOLECULE-1 AND ALPHA. BETA.INTEGRIN; USEFUL FOR THE TREATMENT OF CHRONIC INFLAMMATORY DISEASES SUCH AS MULTIPLE SCLEROSIS, ASTHMA, AND INFLAMMATORY BOWEL DISEASE HOFFMAN-LA ROCHE INC. 2001-05-08 US disclosed
EP-1005445-A1 N-ALKANOYLPHENYLALANINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2000-06-07 EP disclosed
WO-1999010312-A1 N-ALKANOYLPHENYLALANINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1999-03-04 WO disclosed