Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 13/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 13/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 10/20 | 0.53 |
| ▸ | TMIGD3 | P0DMS9 | 7/20 | 0.53 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5356672 | 0.94 | ADORA2A (0.54) | ADORA1ADORA2AADORA3ADORA2BTMIGD3 | |
| SCHEMBL5161117 | 0.91 | ADORA2A (0.59) | ADORA1ADORA2AADORA3ADORA2BTMIGD3 | |
| SCHEMBL5163812 | 0.85 | ADORA1 (0.60) | ADORA1ADORA2AADORA3ADORA2BTMIGD3 | |
| SCHEMBL5164682 | 0.81 | ABCB1 (0.45) | ADORA1ADORA2AADORA3TLR7ALDH1A1 | |
| SCHEMBL5161917 | 0.81 | TLR7 (0.51) | ADORA2AADORA2BTLR7CYP1A2CYP3A4 | |
| SCHEMBL5159098 | 0.80 | TLR7 (0.52) | TLR7CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5160802 | 0.79 | MAPT (0.41) | ADORA1ADORA2ATLR7ALDH1A1CYP1A2 | |
| SCHEMBL5161919 | 0.77 | ADORA2A (0.74) | ADORA1ADORA2AADORA3ADORA2BTMIGD3 | |
| SCHEMBL5161918 | 0.76 | ALDH1A1 (0.49) | ADORA1ADORA2AADORA3ADORA2BTMIGD3 | |
| SCHEMBL5163705 | 0.75 | ADORA2A (0.74) | ADORA1ADORA2AADORA3ADORA2BTMIGD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189730-B2 | A2A adenosine receptor antagonists | CV THERAPEUTICS, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1456209-B1 | A2A ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2007-02-28 | — | — | EP | disclosed |
| US-20030149060-A1 | A2A adenosine receptor antagonists | CV THERAPEUTICS, INC. | 2003-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149060-A1 | A2A adenosine receptor antagonists | ADORA2A, ADORA2B, ADORA3 | ADORA1 4/4885ADORA2A 1/4885ADORA3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.