Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.36 |
| ▸ | MASP2 | O00187 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5167489 | 0.83 | KDM4E (0.50) | KCNQ2MAPTGAAALDH1A1TSHR | |
| SCHEMBL2026957 | 0.76 | PBRM1 (0.49) | MAPTALDH1A1KDM4EPOLBATM | |
| SCHEMBL5317324 | 0.76 | ALDH1A1 (0.53) | MAPTGAAALDH1A1TSHRTP53 | |
| SCHEMBL8793059 | 0.76 | TDP1 (0.49) | MAPTGAAALDH1A1TSHRTP53 | |
| SCHEMBL16318050 | 0.76 | KDM4E (0.54) | GAAALDH1A1KDM4ELPAR2LPAR3 | |
| SCHEMBL15966044 | 0.74 | F2 (0.37) | KCNQ2MAPTGAAALDH1A1TSHR | |
| SCHEMBL15427423 | 0.74 | PLK1 (0.49) | SMN1; SMN2 | |
| SCHEMBL22904381 | 0.74 | FABP4 (0.41) | MAPTALDH1A1KDM4ELPAR2LPAR3 | |
| SCHEMBL2744206 | 0.74 | PBRM1 (0.60) | MAPTALDH1A1TSHRKDM4EFABP4 | |
| SCHEMBL11157305 | 0.74 | ALDH1A1 (0.47) | KCNQ2MAPTGAAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100390148-C | Method for the treatment of malignant tumours | ACTIVE BIOTECH AB (SE) | 2008-05-28 | — | — | CN | disclosed |
| EP-1224172-B1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | ACTIVE BIOTECH AB (SE) | 2007-04-04 | — | — | EP | disclosed |
| CN-1589264-A | Method for the treatment of malignant tumours | ACTIVE BIOTECH AB (SE) | 2005-03-02 | — | — | CN | disclosed |
| US-6605616-B1 | Autoimmune diseases; inflammation | ACTIVE BIOTECH AB (SE) | 2003-08-12 | — | — | US | disclosed |
| EP-1224172-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | Active Biotech AB (SE) | 2002-07-24 | — | — | EP | disclosed |
| US-6395750-B1 | Includes laquinimod, N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-chloro-1-methyl-2-oxo-quinoline-3-carboxamide and its salts; breat or prostate cancer | ACTIVE BIOTECH AB (SE) | 2002-05-28 | — | — | US | disclosed |
| WO-2001030758-A1 | DRUGS FOR THE TREATMENT OF MALIGNANT TUMOURS | ACTIVE BIOTECH AB (SE) | 2001-05-03 | — | — | WO | disclosed |