Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 16/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 14/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5165482 | 0.82 | OPRL1 (0.51) | OPRL1OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL5164801 | 0.81 | OPRL1 (0.52) | OPRL1OPRM1OPRK1 | |
| SCHEMBL4833481 | 0.78 | NPC1 (0.54) | MAOAMAOBNPC1MAPTRAB9A | |
| SCHEMBL5166521 | 0.77 | OPRL1 (0.46) | OPRL1OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL5165834 | 0.76 | OPRL1 (0.47) | OPRL1OPRM1OPRK1 | |
| SCHEMBL5164600 | 0.76 | OPRL1 (0.50) | OPRL1OPRM1OPRK1NPC1RAB9A | |
| SCHEMBL5165836 | 0.75 | OPRL1 (0.45) | OPRL1OPRM1OPRK1 | |
| SCHEMBL22090059 | 0.74 | OPRL1 (0.51) | OPRL1OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL5166664 | 0.74 | OPRL1 (0.46) | OPRL1OPRM1OPRK1 | |
| SCHEMBL3840654 | 0.74 | MAPT (0.64) | MAOAMAOBNPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276518-B2 | Substituted cyclohexane-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-10-02 | — | — | US | claimed |
| EP-1392641-B1 | SUBSTITUTED CYCLOHEXANE-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-04-11 | — | — | EP | claimed |
| US-20040162287-A1 | Substituted cyclohexane-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2004-08-19 | — | — | US | claimed |
| EP-1392641-A1 | SUBSTITUTED CYCLOHEXANE-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2004-03-03 | — | — | EP | claimed |
| WO-2002090317-A1 | SUBSTITUTED CYCLOHEXANE-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2002-11-14 | — | — | WO | claimed |
| US-7276518-B2 | Substituted cyclohexane-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-10-02 | — | — | US | disclosed |
| EP-1392641-B1 | SUBSTITUTED CYCLOHEXANE-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-04-11 | — | — | EP | disclosed |
| US-20040229872-A1 | Substituted cyclohexane-1,4-diamine compounds with anti-diarrhea and peripheral analgesic activity | GRUENENTHAL GMBH (DE) | 2004-11-18 | — | — | US | disclosed |
| US-20040162287-A1 | Substituted cyclohexane-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2004-08-19 | — | — | US | disclosed |
| EP-1392641-A1 | SUBSTITUTED CYCLOHEXANE-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002090317-A1 | SUBSTITUTED CYCLOHEXANE-1,4-DIAMINE DERIVATIVES | Grünenthal GmbH (DE) | 2002-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040162287-A1 | Substituted cyclohexane-1,4-diamine compounds | DPYD, DDC, QDPR | OPRL1 1102/4885OPRM1 459/4885MAOA 71/4885 |
| US-20040229872-A1 | Substituted cyclohexane-1,4-diamine compounds with anti-diarrhea and peripheral analgesic activity | ARG1, CD2, PDCD1 | OPRL1 41/4885OPRM1 250/4885MAOA 2676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.