SCHEMBL5164387

SCHEMBL5164387

COc1cc(C=C(C#N)C(=O)O)cc(OC)c1O

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DNM1 Q05193 5/20 0.61
KMT2A Q03164 7/20 0.60
MEN1 O00255 5/20 0.59
MAPT P10636 5/20 0.59
EGFR P00533 3/20 0.58
PTP4A3 O75365 2/20 0.57
PTP4A2 Q12974 2/20 0.57
PTP4A1 Q93096 2/20 0.57
KDM4E B2RXH2 4/20 0.56
ALDH1A1 P00352 3/20 0.56
SMN1; SMN2 Q16637 3/20 0.56
CYP1A2 P05177 3/20 0.56
LMNA P02545 2/20 0.56
RGS12 O14924 2/20 0.56
GMNN O75496 2/20 0.56
USP2 O75604 2/20 0.56
CYP3A4 P08684 2/20 0.56
CYP2C9 P11712 2/20 0.56
HPGD P15428 2/20 0.56
ALOX15 P16050 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8749247 1.00 DNM1 (0.61) DNM1KMT2AMEN1MAPTEGFR
SCHEMBL7820542 0.94 DNM1 (0.70) DNM1KMT2AMEN1MAPTEGFR
SCHEMBL7820539 0.94 DNM1 (0.70) DNM1KMT2AMEN1MAPTEGFR
SCHEMBL8646383 0.88 KDM4E (0.56) DNM1KMT2AMEN1MAPTKDM4E
SCHEMBL11761701 0.88 KDM4E (0.56) DNM1KMT2AMEN1MAPTKDM4E
SCHEMBL9559164 0.87 EGFR (0.56) DNM1KMT2AMEN1MAPTEGFR
SCHEMBL16148658 0.86 EGFR (0.54) DNM1KMT2AMEN1MAPTEGFR
SCHEMBL16148661 0.86 EGFR (0.54) DNM1KMT2AMEN1MAPTEGFR
SCHEMBL29813583 0.86 EGFR (0.73) DNM1KMT2AMEN1MAPTEGFR
SCHEMBL5597271 0.84 KMT2A (0.70) KMT2AMEN1MAPTEGFRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0403238-A2 Cosmetic composition UNILEVER PLC (GB) 1990-12-19 EP claimed
EP-1759213-A2 ANALYSIS METHOD BIOINVENT INTERNATIONAL AB (SE) 2007-03-07 EP disclosed
WO-2006002841-A2 ANALYSIS METHOD BIOINVENT INTERNATIONAL AB (SE) 2006-01-12 WO disclosed
EP-0571198-B1 Cosmetic composition containing hair-growth promoter UNILEVER PLC (GB) 1997-03-19 EP disclosed
EP-0750498-A1 USE OF ANTAGONISTS OF EGF OR TGF-ALPHA FOR THE TREATMENT AND PROPHYLAXIS OF ACNE UNILEVER PLC (GB) 1997-01-02 EP disclosed
EP-0572167-B1 Cosmetic composition UNILEVER PLC (GB) 1996-10-09 EP disclosed
US-5559092-A HAIR GROWTH, GLUTAMINE DIPEPTIDE CHESEBROUGH-POND'S USA CO. DIVISION OF CONOPCO, INC. (US) 1996-09-24 US disclosed
EP-0490581-B1 Cosmetic composition UNILEVER PLC (GB) 1996-05-22 EP disclosed
EP-0517371-B1 Hair growth composition containing citric acid esters UNILEVER PLC (GB) 1996-01-10 EP disclosed
US-5478856-A Styrene derivatives and salts thereof TAIHO PHARMACEUTICAL CO., LTD. (JP) 1995-12-26 US disclosed
WO-1995024896-A2 USE OF ANTAGONISTS OF EGF OR TGF-ALPHA FOR THE TREATMENT AND PROPHYLAXIS OF ACNE UNILEVER PLC (GB) 1995-09-21 WO disclosed
EP-0623603-A1 STYRENE DERIVATIVE AND SALTS THEREOF TAIHO PHARMACEUTICAL CO., LTD. (JP) 1994-11-09 EP disclosed
EP-0580409-A2 Cosmetic composition containing DOPA derivatives UNILEVER PLC (GB) 1994-01-26 EP disclosed
EP-0572167-A1 Cosmestic composition UNILEVER PLC (GB) 1993-12-01 EP disclosed
EP-0571198-A1 Cosmetic composition containing hair-growth promoter UNILEVER PLC (GB) 1993-11-24 EP disclosed
EP-0517371-A2 Hair growth composition containing citric acid esters UNILEVER PLC (GB) 1992-12-09 EP disclosed
US-5124354-A Hair growth CHESEBROUGH POND'S USA CO., DIVISION OF CONOPCO, INC. (US) 1992-06-23 US disclosed