Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.35 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA3 | P07451 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA6 | P23280 | 2/20 | 0.38 |
| ▸ | CA5A | P35218 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7862753 | 0.98 | DNM1 (0.40) | DNM1CA12CA1CA2CA3 | |
| SCHEMBL6868041 | 0.93 | CA12 (0.40) | DNM1CA12CA1CA2CA3 | |
| SCHEMBL16416350 | 0.91 | CPB2 (0.41) | DNM1CA12CA1CA2CA3 | |
| SCHEMBL11967584 | 0.91 | CPB2 (0.41) | DNM1CA12CA1CA2CA3 | |
| SCHEMBL27975115 | 0.90 | GRIN2D (0.38) | DNM1CA12CA1CA2CA3 | |
| SCHEMBL24838601 | 0.85 | — | — | |
| SCHEMBL9551519 | 0.82 | GRIN2D (0.36) | DNM1CA12CA1CA2CA3 | |
| SCHEMBL3193842 | 0.80 | GRIN2D (0.34) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL30895346 | 0.76 | GRIN2D (0.39) | DNM1CA12CA1CA2CA3 | |
| SCHEMBL8416075 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820338-B1 | WHOLE BLOOD SEPARATION METHOD AND DEVICES | LIFESCAN INC (US) | 2007-03-14 | — | — | EP | disclosed |
| EP-1361436-B1 | Multilayer reagent test strips and methods for using the same to quantify glycated protein in a physiological sample | LIFESCAN INC (US) | 2006-11-15 | — | — | EP | disclosed |
| US-20050255453-A1 | Multilayer reagent test strips and methods for using the same to quantify glycated protein in a physiological sample | LIFESCAN, INC. | 2005-11-17 | — | — | US | disclosed |
| US-6951728-B2 | Multilayer reagent test strips to quantify glycated protein in a physiological sample | LIFESCAN, INC. (US) | 2005-10-04 | — | — | US | disclosed |
| US-20030211564-A1 | Multilayer reagent test strips and methods for using the same to quantify glycated protein in a physiological sample | LIFESCAN IP HOLDINGS, LLC | 2003-11-13 | — | — | US | disclosed |
| EP-1361436-A1 | Multilayer reagent test strips and methods for using the same to quantify glycated protein in a physiological sample | Lifescan, Inc. (US) | 2003-11-12 | — | — | EP | disclosed |
| EP-0820338-A4 | WHOLE BLOOD SEPARATION METHOD AND DEVICES | LXN CORP (US) | 1998-12-09 | — | — | EP | disclosed |
| US-5762871-A | ANALYZING FRUCTOSAMINE OR GLUCOSE IN BLOOD SAMPLE | LXN CORP. (US) | 1998-06-09 | — | — | US | disclosed |
| US-5725774-A | PERMEABLE MATRIX CONTAINING POLYOL THAT CLUMPS ERYTHROCYTES; TEST FOR GLUCOSE OR FRUCTOSAMINE | LXN CORP. (US) | 1998-03-10 | — | — | US | disclosed |
| EP-0820338-A1 | WHOLE BLOOD SEPARATION METHOD AND DEVICES | LXN Corporation (US) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996031270-A1 | WHOLE BLOOD SEPARATION METHOD AND DEVICES | LXN CORPORATION (US) | 1996-10-10 | — | — | WO | disclosed |