Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739767 | 0.89 | UTS2R (0.42) | HTR2AADRA2BADRA2CSLC6A2SLC6A4 | |
| SCHEMBL14017766 | 0.86 | ADRA2B (0.50) | HTR2AADRA2BADRA2CSLC6A2SLC6A4 | |
| SCHEMBL13452589 | 0.86 | ADRA2B (0.50) | HTR2AADRA2BADRA2CSLC6A2SLC6A4 | |
| SCHEMBL5390976 | 0.82 | TSHR (0.44) | ALDH1A1TSHRTRPA1AOC3NPC1 | |
| SCHEMBL5325814 | 0.81 | TMEM97 (0.42) | HTR2AADRA2BADRA2CSLC6A2SLC6A4 | |
| SCHEMBL4740861 | 0.80 | TNF (0.50) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9995387 | 0.80 | CHRNB2 (0.56) | HTR2ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL12071516 | 0.80 | CHRNB2 (0.56) | HTR2ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL5398515 | 0.80 | CHRNB2 (0.56) | HTR2ASLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL28144244 | 0.80 | CHRNB2 (0.56) | HTR2ASLC6A2SLC6A4SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765766-A1 | METHOD FOR PRODUCING ENANTIOMERS 3-HYDROXY-3-PHENYL-PROPYLAMINES | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006005476-A1 | METHOD FOR PRODUCING ENANTIOMERS 3-HYDROXY-3-PHENYL-PROPYLAMINES | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2006-01-19 | — | — | WO | disclosed |
| EP-1567501-A1 | PROPANAMINE DERIVATIVES AS SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004043931-A1 | PROPANAMINE DERIVATIVES AS SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2004-05-27 | — | — | WO | disclosed |