Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.49 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29249591 | 0.82 | MEN1 (0.42) | MEN1KMT2ATRPV4AKR1B10MMP2 | |
| SCHEMBL5166422 | 0.82 | AKR1B10 (0.51) | MEN1KMT2ATRPV4AKR1B10MMP2 | |
| SCHEMBL5165720 | 0.81 | AKR1B10 (0.54) | MEN1KMT2ATRPV4AKR1B10MMP2 | |
| Methane SCHEMBL27993257 | 0.81 | MEN1 (0.60) | MEN1KMT2ATRPV4AKR1B10MMP2 | |
| SCHEMBL4104687 | 0.79 | MEN1 (1.00) | MEN1KMT2ATRPV4AKR1B10MMP2 | |
| SCHEMBL27028792 | 0.76 | CYP19A1 (0.51) | MEN1KMT2AAKR1B1MAOBHTT | |
| SCHEMBL11116300 | 0.75 | MEN1 (0.40) | MEN1KMT2ATRPV4MAOBHTT | |
| SCHEMBL30199523 | 0.74 | AKR1B10 (0.63) | MEN1KMT2AAKR1B10MMP2AKR1B1 | |
| SCHEMBL12733155 | 0.72 | AKR1B10 (0.56) | MEN1KMT2ATRPV4AKR1B10MMP2 | |
| SCHEMBL7898977 | 0.72 | CYP19A1 (0.55) | MEN1KMT2AAKR1B1MAOBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768945-A1 | SUBSTITUTED HYDROXYACETOPHENON DERIVATIVES | Riemser Arzneimittel AG (DE) | 2007-04-04 | — | — | EP | claimed |
| WO-2006003010-A1 | SUBSTITUTED HYDROXYACETOPHENON DERIVATIVES | RIEMSER ARZNEIMITTEL AG (DE) | 2006-01-12 | — | — | WO | claimed |
| EP-1768945-A1 | SUBSTITUTED HYDROXYACETOPHENON DERIVATIVES | Riemser Arzneimittel AG (DE) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006003010-A1 | SUBSTITUTED HYDROXYACETOPHENON DERIVATIVES | RIEMSER ARZNEIMITTEL AG (DE) | 2006-01-12 | — | — | WO | disclosed |