Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2037519 | 0.79 | ALDH1A1 (0.40) | JAK2IRAK4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28766873 | 0.76 | HTR2A (0.47) | SLC6A2SLC6A4 | |
| SCHEMBL8791343 | 0.74 | ALOX15 (0.41) | ALOX15SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5164769 | 0.72 | HTR2A (0.36) | IKBKBJAK2IRAK4 | |
| SCHEMBL2028286 | 0.71 | ALDH1A1 (0.44) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3184582 | 0.68 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7819920 | 0.67 | GRM2 (0.36) | SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL6599442 | 0.67 | SLC6A2 (0.36) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2031773 | 0.65 | ALDH1A1 (0.45) | JAK2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5833614 | 0.65 | NOS3 (0.49) | IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765808-A1 | BISARYLUREA DERIVATIVES USEFUL FOR INHIBITING CHK1 | ICOS Corporation (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006012308-A1 | BISARYLUREA DERIVATIVES USEFUL FOR INHIBITING CHK1 | ICOS CORPORATION (US) | 2006-02-02 | — | — | WO | disclosed |