SCHEMBL5166000

SCHEMBL5166000

Cc1cc(Cl)c(C(=O)c2cc(C)c(C)cc2Cl)cc1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.41
MAPK13 O15264 7/20 0.41
MAPK12 P53778 7/20 0.41
MAPK11 Q15759 7/20 0.41
MAPK14 Q16539 7/20 0.41
SMN1; SMN2 Q16637 3/20 0.37
TSHR P16473 1/20 0.37
CASP1 P29466 1/20 0.37
MYC P01106 1/20 0.36
NR4A1 P22736 1/20 0.36
RAB9A P51151 3/20 0.35
NPC1 O15118 2/20 0.35
RXRA P19793 1/20 0.35
DAO P14920 1/20 0.34
MAPT P10636 1/20 0.34
MEN1 O00255 1/20 0.34
USP2 O75604 1/20 0.34
POLB P06746 1/20 0.34
ALOX15 P16050 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10628886 0.83 ALDH1A1 (0.50) ALDH1A1SMN1; SMN2TSHRCASP1MYC
SCHEMBL10630827 0.83 SMN1; SMN2 (0.35) ALDH1A1MAPK13MAPK12MAPK11MAPK14
SCHEMBL20194580 0.81 CA12 (0.50) ALDH1A1CASP1MAPTPOLBKMT2A
SCHEMBL3328565 0.79 ALDH1A1 (0.42) ALDH1A1MAPK13MAPK12MAPK11MAPK14
SCHEMBL14590043 0.78 GAA (0.47) ALDH1A1SMN1; SMN2TSHRMAPTMEN1
SCHEMBL7528224 0.76 GSK3B (0.39) ALDH1A1RAB9AMAPTMEN1KMT2A
SCHEMBL11848942 0.75 SRD5A2 (0.54) ALDH1A1SMN1; SMN2TSHRCASP1RAB9A
SCHEMBL22490276 0.75 HPGD (0.66) ALDH1A1SMN1; SMN2RAB9ANPC1POLB
SCHEMBL11851691 0.75 ALDH1A1 (0.52) ALDH1A1SMN1; SMN2TSHRCASP1MYC
SCHEMBL3327663 0.74 ATM (0.37) ALDH1A1SMN1; SMN2TSHRRAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1222237-B1 MATERIALS FOR INDUCING ALIGNMENT IN LIQUID CRYSTALS AND LIQUID CRYSTAL DISPLAYS ELSICON INC (US) 2007-04-11 EP disclosed
EP-1155353-B1 MATERIALS FOR INDUCING ALIGNMENT OF LIQUID CRYSTALS AND LIQUID CRYSTAL OPTICAL ELEMENTS ELSICON INC (US) 2006-10-04 EP disclosed
US-6991834-B1 Materials for inducing alignment of liquid crystals and liquid crystal optical elements ELSICON, INC. (US) 2006-01-31 US disclosed
EP-1155353-A4 MATERIALS FOR INDUCING ALIGNMENT OF LIQUID CRYSTALS AND LIQUID CRYSTAL OPTICAL ELEMENTS ELSICON INC (US) 2003-04-23 EP disclosed
EP-1222237-A4 MATERIALS FOR INDUCING ALIGNMENT IN LIQUID CRYSTALS AND LIQUID CRYSTAL DISPLAYS ELSICON INC (US) 2003-01-15 EP disclosed
US-6491988-B1 POLYAMIC ACID, POLYAMIDE ESTER AND POLYIMIDES; ANISOTROPICALLY ABSORBING; EXPOSING LAYER TO POLARIZED LIGHT; CROSSLINKING DIAMINES HAVING SIDE CHAINS OF C3-C22 LINEAR AND BRANCHED AND PARTIALLY FLUORINATED HYDROCARBONSCHAINS ELSICON, INC. 2002-12-10 US disclosed
EP-1222237-A1 MATERIALS FOR INDUCING ALIGNMENT IN LIQUID CRYSTALS AND LIQUID CRYSTAL DISPLAYS Elsicon, Inc. (US) 2002-07-17 EP disclosed
US-6380432-B2 AROMATIC DIAMINES USEFUL IN PREPARING POLYIMIDES ELSICON INC. 2002-04-30 US disclosed
EP-1155353-A1 MATERIALS FOR INDUCING ALIGNMENT OF LIQUID CRYSTALS AND LIQUID CRYSTAL OPTICAL ELEMENTS Elsicon Inc. (US) 2001-11-21 EP disclosed
US-20010039361-A1 Materials for inducing alignment in liquid crystal and liquid crystal displays GIBBONS WAYNE M (US) 2001-11-08 US disclosed
US-5807498-A EXPOSURE TO POLARIZED LIGHT ALLIANT TECHSYSTEMS INC. (US) 1998-09-15 US disclosed
US-5731405-A POLYIMIDE COPOLYMER MADE FROM DIARYL KETONE TETRACARBOXYLIC DIANHYDRIDE, HYDROPHOBIC DIAMINE, AND ALICYCLIC TETRACARBOXYLIC ANHYDRIDE REACTANTS ALLIANT TECHSYSTEMS INC. (US) 1998-03-24 US disclosed
WO-1997037274-A2 PROCESS AND MATERIALS FOR ALIGNING LIQUID CRYSTALS AND LIQUID CRYSTAL OPTICAL ELEMENTS ALLIANT TECHSYSTEMS INC. (US) 1997-10-09 WO disclosed
US-5153303-A Polyimides prepared from disubstituted aromatic tetracarboxylic acid dianhydrides CIBA-GEIGY CORPORATION (US) 1992-10-06 US disclosed
US-5077415-A Disubstituted aromatic dianhydrides CIBA-GEIGY CORPORATION (US) 1991-12-31 US disclosed
EP-0438382-A1 Disubstituted aromatic dianhydrides and polyimides prepared therefrom CIBA-GEIGY AG (CH) 1991-07-24 EP disclosed
US-4914182-A AUTOPHOTOCROSSLINKABLE; PROTECTIVE FILMS, PHOTOGRAPHIC RELIEF IMAGES CIBA-GEIGY CORPORATION (US) 1990-04-03 US disclosed
US-4914181-A AUTOPHOTOCROSSLINKABLE; BASED ON CARBONYL-CONTAINING TETRACARBOXYLIC ACIDS AND ACYCLIC OR CARBO DIAMINES; PROTECTIVE COATINGS; PHOTORESISTS; VARNISHES; LACQUERS SEMICONDUCTORS CIBA-GEIGY CORPORATION (US) 1990-04-03 US disclosed
US-4698295-A AUTOMATIC PHOTOCROSSLINKING CIBA-GEIGY CORPORATION (US) 1987-10-06 US disclosed
EP-0181837-A2 Process for the manufacture of films and relief pictures from polyimides CIBA-GEIGY AG (CH) 1986-05-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010039361-A1 Materials for inducing alignment in liquid crystal and liquid crystal displays DYNC1LI1, DYNC1LI2, DYNLL1 ALDH1A1 1492/4885MAPK13 1240/4885MAPK12 1241/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.