SCHEMBL5166027

SCHEMBL5166027

C=C(CN(C)Cc1ccc2ccccc2c1)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PYCR1 P32322 1/20 0.52
ACHE P22303 1/20 0.51
MAOA P21397 3/20 0.50
MAOB P27338 3/20 0.50
SIGMAR1 Q99720 2/20 0.45
CYP1A2 P05177 1/20 0.42
CYP2A6 P11509 1/20 0.42
OPRM1 P35372 1/20 0.41
TMEM97 Q5BJF2 1/20 0.41
BCHE P06276 2/20 0.41
SLC6A2 P23975 2/20 0.40
SLC6A4 P31645 2/20 0.40
SLC6A3 Q01959 2/20 0.40
LSS P48449 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5169170 0.87 PYCR1 (0.46) PYCR1ACHEMAOAMAOBSIGMAR1
SCHEMBL9779259 0.82 MAOA (0.60) PYCR1MAOAMAOBSIGMAR1
SCHEMBL5167798 0.79 ACHE (0.51) PYCR1ACHESIGMAR1OPRM1TMEM97
SCHEMBL16015735 0.77 PYCR1 (0.56) PYCR1ACHESIGMAR1CYP1A2CYP2A6
SCHEMBL5165543 0.77 MAOA (0.50) ACHEMAOAMAOBSIGMAR1TMEM97
Hydrochloric Acid SCHEMBL5168719 0.75 MAOA (0.51) ACHEMAOAMAOBSIGMAR1TMEM97
SCHEMBL5167343 0.75 MAOA (0.49) ACHEMAOAMAOBSIGMAR1TMEM97
SCHEMBL23423745 0.74 PYCR1 (0.65) PYCR1ACHESIGMAR1CYP1A2CYP2A6
SCHEMBL5168255 0.73 CYP2D6 (0.63) ACHEMAOAMAOBSIGMAR1CYP1A2
SCHEMBL16377075 0.73 PYCR1 (0.52) PYCR1ACHEMAOBSIGMAR1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1561744-B1 AMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND THEIR USE AS ANTIMYCOTIC AGENT POLA CHEM IND INC (JP) 2007-04-18 EP claimed
EP-1561744-A2 AMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND THEIR USE AS ANTIMYCOTIC AGENT POLA CHEMICAL INDUSTRIES INC. (JP) 2005-08-10 EP claimed
US-6329399-B1 Antifungal amine derivatives and processing for producing the same POLA CHEMICAL INDUSTRIES, INC. (JP) 2001-12-11 US claimed
EP-1020426-A1 AMINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME POLA CHEMICAL INDUSTRIES, INC. (JP) 2000-07-19 EP claimed
EP-1561744-B1 AMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND THEIR USE AS ANTIMYCOTIC AGENT POLA CHEM IND INC (JP) 2007-04-18 EP disclosed
EP-1561744-A2 AMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND THEIR USE AS ANTIMYCOTIC AGENT POLA CHEMICAL INDUSTRIES INC. (JP) 2005-08-10 EP disclosed
US-6329399-B1 Antifungal amine derivatives and processing for producing the same POLA CHEMICAL INDUSTRIES, INC. (JP) 2001-12-11 US disclosed
EP-1020426-A1 AMINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME POLA CHEMICAL INDUSTRIES, INC. (JP) 2000-07-19 EP disclosed