Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 17/20 | 0.54 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3787514 | 0.91 | MCL1 (0.44) | MCL1BCL2L1GRIK1 | |
| SCHEMBL3782300 | 0.76 | ALDH1A1 (0.45) | GRIK1 | |
| SCHEMBL3779405 | 0.76 | CASP3 (0.47) | GRIK1 | |
| SCHEMBL3790641 | 0.75 | CASP3 (0.44) | MCL1 | |
| SCHEMBL3790633 | 0.74 | NPC1 (0.47) | — | |
| SCHEMBL3788012 | 0.74 | CASP3 (0.43) | MCL1 | |
| SCHEMBL3784801 | 0.73 | KMT2A (0.51) | GRIK1 | |
| SCHEMBL5179992 | 0.72 | CCKBR (0.36) | — | |
| SCHEMBL5168453 | 0.72 | CASP3 (0.43) | GRIK1 | |
| SCHEMBL18392239 | 0.70 | MCL1 (1.00) | MCL1BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142586-B1 | USE OF CHYMASE INHIBITORS AGAINST VASCULAR LIPID DEPOSITION | DAIICHI ASUBIO PHARMA CO LTD (JP) | 2007-04-25 | — | — | EP | disclosed |
| CN-1245979-C | Medicine for preventing and treating dermatitis containing chymase inhibitor as active ingredient | DAIICHI ASBIAO PHARMACEUTICAL (JP) | 2006-03-22 | — | — | CN | disclosed |
| CN-1245978-C | Preventive and therapeutic agent for various diseases associated with eosinophilia comprising chymase inhibitor as active ingredient | DAIICHI ASBIAO PHARMACEUTICAL (JP) | 2006-03-22 | — | — | CN | disclosed |
| US-6921766-B1 | Blood vessel lipid deposition-preventive agent comprising chymase-inhibitor | DAIICHI SUNTORY PHARMA CO., LTD. (JP) | 2005-07-26 | — | — | US | disclosed |
| CN-1366460-A | Preventive or therapeutic drugs for fibrosis containing chymase inhibitors as active ingredient | SUNTORY LTD (JP) | 2002-08-28 | — | — | CN | disclosed |
| CN-1366459-A | Preventive and therapeutic agent for various diseases associated with eosinophilia comprising chymase inhibitor as active ingredient | SUNTORY LTD (JP) | 2002-08-28 | — | — | CN | disclosed |
| CN-1366461-A | Preventive or therapeutic drugs for dermatitises containing chymase inhibitors as active ingredient | SUNTORY LTD (JP) | 2002-08-28 | — | — | CN | disclosed |
| EP-1142586-A1 | INHIBITORS AGAINST VASCULAR LIPID DEPOSITION CONTAINING CHYMASE-INHIBITING SUBSTANCES | SUNTORY LIMITED (JP) | 2001-10-10 | — | — | EP | disclosed |