Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TAS2R14 | Q9NYV8 | 7/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22482261 | 0.87 | KDM4E (0.46) | MEN1KMT2AL3MBTL1ALDH1A1HDAC3 | |
| SCHEMBL4479586 | 0.84 | TAS2R14 (0.57) | MEN1KMT2ATAS2R14L3MBTL1ALDH1A1 | |
| SCHEMBL4479581 | 0.84 | TAS2R14 (0.57) | MEN1KMT2ATAS2R14L3MBTL1ALDH1A1 | |
| SCHEMBL785821 | 0.79 | ACHE (0.49) | ACHE | |
| SCHEMBL7814243 | 0.79 | POLB (0.54) | TAS2R14L3MBTL1ALDH1A1GAAKDM4E | |
| SCHEMBL1965678 | 0.79 | TAS2R14 (0.49) | MEN1KMT2ATAS2R14L3MBTL1ALDH1A1 | |
| SCHEMBL784983 | 0.76 | GBA1 (0.56) | KDM4EHSD17B10 | |
| Trifluoroacetic Acid SCHEMBL785809 | 0.76 | SLC6A2 (0.46) | MEN1KMT2A | |
| SCHEMBL3515654 | 0.75 | GBA1 (0.53) | MEN1KMT2AL3MBTL1ALDH1A1GAA | |
| SCHEMBL1662783 | 0.75 | GBA1 (0.53) | MEN1KMT2AL3MBTL1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765791-A1 | PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006014482-A1 | PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF PKC-THETA | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-02-09 | — | — | WO | disclosed |