Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 4/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5164225 | 1.00 | OPRL1 (0.48) | OPRL1OPRM1LMNAGAAHTR1D | |
| SCHEMBL5164684 | 0.83 | OPRL1 (0.70) | OPRL1OPRM1HTR1DHTR1BADRB1 | |
| SCHEMBL12918432 | 0.83 | OPRL1 (0.70) | OPRL1OPRM1HTR1DHTR1BADRB1 | |
| SCHEMBL5164787 | 0.83 | OPRL1 (0.69) | OPRL1OPRM1LMNAGAAMAPT | |
| Hydrochloric Acid SCHEMBL5164066 | 0.82 | OPRL1 (0.69) | OPRL1OPRM1HTR1DHTR1BADRB1 | |
| Hydrochloric Acid SCHEMBL5164262 | 0.82 | OPRL1 (0.68) | OPRL1OPRM1LMNAGAAMAPT | |
| SCHEMBL5164138 | 0.78 | OPRL1 (0.52) | OPRL1OPRM1HTR1DHTR1BADRB1 | |
| Hydrochloric Acid SCHEMBL5164593 | 0.77 | OPRL1 (0.51) | OPRL1OPRM1HTR1DHTR1BADRB1 | |
| SCHEMBL30353988 | 0.77 | HTR2A (0.51) | LMNAHTR1DHTR1BADRB1HTR1A | |
| SCHEMBL19412077 | 0.77 | HTR2A (0.51) | LMNAHTR1DHTR1BADRB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276518-B2 | Substituted cyclohexane-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-10-02 | — | — | US | disclosed |
| EP-1392641-B1 | SUBSTITUTED CYCLOHEXANE-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2007-04-11 | — | — | EP | disclosed |
| US-20040229872-A1 | Substituted cyclohexane-1,4-diamine compounds with anti-diarrhea and peripheral analgesic activity | GRUENENTHAL GMBH (DE) | 2004-11-18 | — | — | US | disclosed |
| US-20040162287-A1 | Substituted cyclohexane-1,4-diamine compounds | GRUENENTHAL GMBH (DE) | 2004-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040162287-A1 | Substituted cyclohexane-1,4-diamine compounds | DPYD, DDC, QDPR | OPRL1 1102/4885OPRM1 459/4885LMNA 2350/4885 |
| US-20040229872-A1 | Substituted cyclohexane-1,4-diamine compounds with anti-diarrhea and peripheral analgesic activity | ARG1, CD2, PDCD1 | OPRL1 41/4885OPRM1 250/4885LMNA 4818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.