Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 6/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.34 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5178441 | 0.89 | NR1H2 (0.38) | NR1H2NR1H3ACLYEP300HIF1A | |
| SCHEMBL5166577 | 0.84 | ALDH1A1 (0.41) | NR1H2NR1H3ACLYHTTLMNA | |
| SCHEMBL5163077 | 0.83 | LMNA (0.40) | NR1H2NR1H3ACLYHTTLMNA | |
| SCHEMBL5167005 | 0.83 | NR1H2 (0.42) | NR1H2NR1H3ACLYHIF1ALMNA | |
| SCHEMBL5164531 | 0.82 | NR1H2 (0.40) | NR1H2NR1H3ACLYHTTLMNA | |
| SCHEMBL5165874 | 0.82 | ACLY (0.44) | NR1H2NR1H3ACLYHTTLMNA | |
| SCHEMBL5164817 | 0.82 | PTPN1 (0.42) | NR1H2NR1H3ACLYHTTLMNA | |
| SCHEMBL5164630 | 0.82 | ACLY (0.42) | NR1H2NR1H3ACLYHTTLMNA | |
| SCHEMBL5165472 | 0.81 | GSK3B (0.37) | NR1H2NR1H3MAPTNPSR1ALDH1A1 | |
| SCHEMBL5163888 | 0.81 | ALDH1A1 (0.42) | LMNANPSR1ALDH1A1TAS2R14KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765332-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | Cengent Therapeutics, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006009876-A2 | TRISUBSTITUTED NITROGEN MODULATORS OF TYROSINE PHOSPHATASES | CENGENT THERAPEUTICS, INC. (US) | 2006-01-26 | — | — | WO | disclosed |