Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5149238 | 0.81 | SIGMAR1 (0.72) | SIGMAR1KMT2AHTR7CXCR4PSEN1 | |
| SCHEMBL17333669 | 0.73 | TDP1 (0.58) | KMT2AMEN1 | |
| SCHEMBL28029094 | 0.73 | HTR2A (0.48) | SIGMAR1HTR7 | |
| SCHEMBL3856135 | 0.73 | SLC6A2 (0.48) | SIGMAR1KMT2AHTR7ALDH1A1SLC6A3 | |
| SCHEMBL14476103 | 0.71 | MEN1 (0.73) | SIGMAR1KMT2AHTR7ALDH1A1SLC6A3 | |
| SCHEMBL28092811 | 0.71 | SIGMAR1 (0.58) | SIGMAR1HTR7ALDH1A1CXCR4ATM | |
| SCHEMBL7261119 | 0.70 | TDP1 (0.69) | — | |
| SCHEMBL13604236 | 0.70 | KMT2A (0.71) | SIGMAR1KMT2AHTR7ALDH1A1SLC6A3 | |
| SCHEMBL1682264 | 0.70 | CXCR4 (0.53) | SIGMAR1KMT2AALDH1A1CXCR4MEN1 | |
| SCHEMBL4271065 | 0.70 | SIGMAR1 (0.97) | SIGMAR1ALDH1A1CXCR4PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809614-A2 | BENZOTRIAZINE INHIBITORS OF KINASES | Targegen, Inc. (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2005096784-A2 | BENZOTRIAZINE INHIBITORS OF KINASES | TARGEGEN, INC. (US) | 2005-10-20 | — | — | WO | disclosed |