Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.72 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.57 |
| ▸ | PTGES | O14684 | 1/20 | 0.49 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28092811 | 0.89 | SIGMAR1 (0.58) | SIGMAR1CXCR4PTGESCCR5HTR2A | |
| SCHEMBL28092846 | 0.87 | MEN1 (0.58) | SIGMAR1PTGESCCR5KMT2A | |
| SCHEMBL14468188 | 0.86 | SIGMAR1 (0.74) | SIGMAR1CXCR4HTR2AHTR2CSRC | |
| SCHEMBL27746879 | 0.85 | SIGMAR1 (0.68) | SIGMAR1CXCR4SRCKMT2A | |
| SCHEMBL4271065 | 0.85 | SIGMAR1 (0.97) | SIGMAR1CXCR4SRCPSEN1PSEN2 | |
| SCHEMBL6338588 | 0.83 | SIGMAR1 (0.62) | SIGMAR1CXCR4HTR2AHTR2CKMT2A | |
| SCHEMBL5431476 | 0.83 | SIGMAR1 (0.59) | SIGMAR1CXCR4SRC | |
| SCHEMBL14445631 | 0.82 | SIGMAR1 (0.69) | SIGMAR1CXCR4HTR2AHTR2CSRC | |
| SCHEMBL5167539 | 0.81 | SIGMAR1 (0.52) | SIGMAR1CXCR4KMT2AHRH3PSEN1 | |
| SCHEMBL15830503 | 0.80 | SIGMAR1 (0.58) | SIGMAR1CXCR4HTR2AHTR2CSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101426772-B | Benzotriazine inhibitors of kinases | TARGEGEN INC | 2014-01-08 | — | — | CN | disclosed |
| EP-1809614-A2 | BENZOTRIAZINE INHIBITORS OF KINASES | Targegen, Inc. (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2005096784-A2 | BENZOTRIAZINE INHIBITORS OF KINASES | TARGEGEN, INC. (US) | 2005-10-20 | — | — | WO | disclosed |