Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL579426 | 0.98 | ALDH1A1 (0.68) | ALDH1A1TDP1CYP3A4TSHRCASP6 | |
| SCHEMBL30696914 | 0.98 | ALDH1A1 (0.68) | ALDH1A1TDP1CYP3A4TSHRCASP6 | |
| SCHEMBL9735773 | 0.92 | ALDH1A1 (0.69) | ALDH1A1TDP1CYP3A4TSHRCASP6 | |
| SCHEMBL9734521 | 0.90 | ALDH1A1 (0.67) | ALDH1A1TDP1CYP3A4TSHRCASP6 | |
| Benzoquinone SCHEMBL28192198 | 0.90 | ALDH1A1 (0.58) | ALDH1A1TDP1CYP3A4TSHRCASP6 | |
| SCHEMBL28197400 | 0.88 | TDP1 (0.54) | ALDH1A1TDP1CYP3A4TSHRCASP6 | |
| SCHEMBL28257118 | 0.88 | TDP1 (0.54) | ALDH1A1TDP1CYP3A4TSHRCASP6 | |
| Naphthoquinone SCHEMBL28243040 | 0.85 | ALDH1A1 (0.53) | ALDH1A1TDP1CYP3A4TSHRCASP6 | |
| SCHEMBL14183908 | 0.84 | ALDH1A1 (0.55) | ALDH1A1TDP1CYP3A4TSHRCASP6 | |
| SCHEMBL28749541 | 0.84 | ALDH1A1 (0.55) | ALDH1A1TDP1CYP3A4TSHRCASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7250438-B2 | Anti-bacterial and anti-cancer spiro beta-lactone/gamma-lactams | NEREUS PHARMACEUTICALS, INC. (US) | 2007-07-31 | — | — | US | disclosed |
| WO-2005121148-A9 | ANTI-BACTERIAL AND ANTI-CANCER SPIRO BETA-LACTONE/GAMMA-LACTAMS | — | 2006-04-27 | — | — | WO | disclosed |
| US-20060004079-A1 | Anti-bacterial and anti-cancer spiro beta-lactone/gamma-lactams | PACIFIC VENTURE GROUP II, L.P. | 2006-01-05 | — | — | US | disclosed |
| WO-2005121148-A2 | ANTI-BACTERIAL AND ANTI-CANCER SPIRO BETA-LACTONE/GAMMA-LACTAMS | NEREUS PHARMACEUTICALS, INC. (US) | 2005-12-22 | — | — | WO | disclosed |
| EP-0649022-B1 | Optical indicator for determining the activity of an ion in a sample | AVL MEDICAL INSTR AG (CH) | 1998-11-04 | — | — | EP | disclosed |
| EP-0705244-B1 | NITRATO AMINO ACID DISULPHIDES FOR USE IN THE THERAPY OF DISORDERS OF THE CARDIOVASCULARY SYSTEM | SANOL ARZNEI SCHWARZ GMBH (DE) | 1998-11-04 | — | — | EP | disclosed |
| US-5723340-A | COMPLEXING DIAMIDE IONOPHORE WITH LITHIUM, SODIUM, MAGNESIUM, OR CALCIUM; FLUORESCENCE | AVL MEDICAL INSTRUMENTS AG (CH) | 1998-03-03 | — | — | US | disclosed |
| EP-0705244-A1 | NITRATO AMINO ACID DISULPHIDES FOR USE IN THE THERAPY OF DISORDERS OF THE CARDIOVASCULARY SYSTEM | SCHWARZ PHARMA AG (DE) | 1996-04-10 | — | — | EP | disclosed |
| EP-0649022-A1 | Optical indicator for determining the activity of an ion in a sample | AVL Medical Instruments AG (CH) | 1995-04-19 | — | — | EP | disclosed |
| WO-1995000477-A1 | NITRATO AMINO ACID DISULPHIDES FOR USE IN THE THERAPY OF DISORDERS OF THE CARDIOVASCULARY SYSTEM | SCHWARZ PHARMA AG (DE) | 1995-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004079-A1 | Anti-bacterial and anti-cancer spiro beta-lactone/gamma-lactams | GLB1, PGLS, LBR | ALDH1A1 1675/4885TDP1 4133/4885CYP3A4 3135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.