Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL340328 | 0.88 | MAPT (0.44) | MAPTALDH1A1KDM4EKMT2ACA12 | |
| SCHEMBL5145077 | 0.85 | KMT2A (0.49) | ALDH1A1KDM4EKMT2ACA12CA1 | |
| SCHEMBL16533324 | 0.84 | MAPT (0.61) | MAPTALDH1A1KDM4EKMT2ACA12 | |
| SCHEMBL5145663 | 0.84 | PDK1 (0.38) | MAPTALDH1A1KMT2AMAPK1BCL2L1 | |
| Hydrochloric Acid SCHEMBL5145668 | 0.84 | KMT2A (0.47) | ALDH1A1KDM4EKMT2ACA12CA1 | |
| SCHEMBL5143539 | 0.80 | BCL2L1 (0.53) | MAPTALDH1A1KDM4EKMT2ALMNA | |
| SCHEMBL24425908 | 0.80 | MAPT (0.50) | MAPTALDH1A1KDM4EKMT2ACA12 | |
| SCHEMBL2827824 | 0.78 | NOTUM (0.56) | MAPTALDH1A1KDM4EKMT2ACA12 | |
| SCHEMBL6568018 | 0.78 | MAPT (0.66) | MAPTALDH1A1KDM4EKMT2ACA12 | |
| SCHEMBL28663604 | 0.78 | MAPT (0.66) | MAPTALDH1A1KDM4EKMT2ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070123592-A1 | Terephthalamide peptidomimetic compounds and methods | YALE UNIVERSITY (US) | 2007-05-31 | — | — | US | disclosed |
| US-20070123592-A1 | Terephthalamide peptidomimetic compounds and methods | YALE UNIVERSITY (US) | 2007-05-31 | — | — | US | disclosed |
| EP-1723100-A4 | TEREPHTHALAMIDE PEPTIDOMIMETIC COMPOUNDS AND METHODS | UNIV YALE (US) | 2007-04-04 | — | — | EP | disclosed |
| EP-1723100-A2 | TEREPHTHALAMIDE PEPTIDOMIMETIC COMPOUNDS AND METHODS | YALE UNIVERSITY (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005079541-A2 | TEREPHTHALAMIDE PEPTIDOMIMETIC COMPOUNDS AND METHODS | YALE UNIVERSITY (US) | 2005-09-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123592-A1 | Terephthalamide peptidomimetic compounds and methods | CRHBP, ANPEP, DNPEP | MAPT 1192/4885ALDH1A1 4665/4885KDM4E 4496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.