Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 10/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.35 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.35 |
| ▸ | CFD | P00746 | 1/20 | 0.35 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5181701 | 0.84 | NNMT (0.46) | MLNRCYP2D6RXRBSYKAURKB | |
| SCHEMBL3077260 | 0.83 | JAK2 (0.44) | MLNRCYP2D6 | |
| SCHEMBL5168814 | 0.73 | HRH3 (0.47) | MLNRCYP2D6RXRBSYKAURKB | |
| SCHEMBL5660251 | 0.71 | SYK (0.48) | MLNRCYP2D6RXRBSYKAURKB | |
| SCHEMBL5663502 | 0.69 | HRH3 (0.46) | MLNRCYP2D6RXRBSYKAURKB | |
| SCHEMBL3097058 | 0.67 | NNMT (0.49) | MLNRCYP2D6 | |
| SCHEMBL15995001 | 0.66 | NNMT (0.53) | — | |
| SCHEMBL15922514 | 0.65 | BACE1 (0.37) | SYKDGAT1 | |
| SCHEMBL15995242 | 0.65 | L3MBTL1 (0.42) | DGAT1 | |
| SCHEMBL5327478 | 0.63 | APP (0.52) | MLNRRXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |