Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 1/20 | 0.46 |
| ▸ | MLNR | O43193 | 4/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 6/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5168811 | 0.84 | MLNR (0.40) | MLNRCYP2D6RXRBSYKAURKB | |
| SCHEMBL3097058 | 0.81 | NNMT (0.49) | NNMTMLNRCYP2D6PARP1 | |
| SCHEMBL27538900 | 0.75 | NNMT (0.56) | NNMTPARP1NPC1CASP3RAB9A | |
| SCHEMBL5663502 | 0.72 | HRH3 (0.46) | MLNRCYP2D6PARP1RXRBNPC1 | |
| SCHEMBL5660251 | 0.72 | SYK (0.48) | MLNRCYP2D6RXRBSYKAURKB | |
| SCHEMBL4400842 | 0.70 | NNMT (0.49) | NNMT | |
| SCHEMBL5168814 | 0.70 | HRH3 (0.47) | MLNRCYP2D6PARP1RXRBNPC1 | |
| SCHEMBL3077260 | 0.68 | JAK2 (0.44) | MLNRCYP2D6 | |
| SCHEMBL29421563 | 0.65 | NNMT (1.00) | NNMTNPC1RAB9A | |
| SCHEMBL6309037 | 0.65 | NNMT (1.00) | NNMTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |