Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1629692 | 0.77 | MAPT (0.52) | MAPTNPSR1NR3C2CYP1A1CYP1B1 | |
| SCHEMBL15049633 | 0.77 | MAPK9 (0.34) | MAPTALDH1A1KMT2AMAPK9MAPK10 | |
| SCHEMBL12722760 | 0.77 | MAPT (0.51) | MAPTNPC1RAB9ANPSR1CYP1A1 | |
| SCHEMBL15049875 | 0.76 | KMT2A (0.43) | MAPTNPSR1NR3C2ALDH1A1KDM4E | |
| SCHEMBL1628993 | 0.76 | LMNA (0.50) | MAPTNPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL1628982 | 0.75 | MAPT (0.47) | MAPTNPC1RAB9ANPSR1NR3C2 | |
| SCHEMBL1630485 | 0.73 | MAPT (0.49) | MAPTNR3C2ALDH1A1KDM4EHTT | |
| SCHEMBL1628989 | 0.71 | ADORA3 (0.50) | MAPTNPSR1NR3C2ALDH1A1HPGD | |
| SCHEMBL1629506 | 0.70 | RAB9A (0.54) | MAPTNPC1RAB9AALDH1A1MAOB | |
| SCHEMBL1628783 | 0.69 | ADORA3 (0.53) | NPC1RAB9ANR3C2USP2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776346-B1 | 1,5-Diphenylpyrazoles | MERCK PATENT GMBH (DE) | 2013-06-26 | — | — | EP | claimed |
| EP-1776346-A1 | 1,5-DIPHENYLPYRAZOLES | Merck Patent GmbH (DE) | 2007-04-25 | — | — | EP | claimed |
| WO-2006018082-A1 | 1,5-DIPHENYLPYRAZOLES | MERCK PATENT GMBH (DE) | 2006-02-23 | — | — | WO | claimed |
| EP-1776346-B1 | 1,5-Diphenylpyrazoles | MERCK PATENT GMBH (DE) | 2013-06-26 | — | — | EP | disclosed |