Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5170179 | 0.91 | P4HTM (0.40) | HDAC1P4HTMGCKTBXAS1KDM4E | |
| SCHEMBL5170275 | 0.91 | P4HTM (0.40) | HDAC1P4HTMGCKTBXAS1KDM4E | |
| SCHEMBL5195209 | 0.88 | SLC6A2 (0.32) | HDAC1P4HTMAKR1C3AKR1C2MEN1 | |
| SCHEMBL5170448 | 0.87 | THRB (0.45) | HDAC1P4HTMGCKAKR1C3AKR1C2 | |
| SCHEMBL5169616 | 0.82 | MAPKAPK2 (0.31) | HDAC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5168539 | 0.82 | HDAC1 (0.48) | HDAC1ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5170495 | 0.81 | HDAC1 (0.47) | HDAC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5168695 | 0.80 | P4HTM (0.40) | HDAC1P4HTMGCKTBXAS1KDM4E | |
| Acetic Acid SCHEMBL5171407 | 0.79 | HDAC1 (0.46) | HDAC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5191421 | 0.78 | HDAC3 (0.39) | HDAC1P4HTMTBXAS1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776357-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | Astellas Pharma Inc. (JP) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006016680-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | ASTELLAS PHARMA INC. (JP) | 2006-02-16 | — | — | WO | disclosed |