Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.31 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA5A | P35218 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5169616 | 0.94 | MAPKAPK2 (0.31) | SLC6A2SLC6A4SLC6A3HDAC1HDAC3 | |
| SCHEMBL5191421 | 0.91 | HDAC3 (0.39) | SLC6A2SLC6A4SLC6A3HDAC1CYP2D6 | |
| SCHEMBL5170237 | 0.90 | AKR1C3 (0.33) | HDAC1HDAC3HDAC2HDAC6AKR1C3 | |
| SCHEMBL5195227 | 0.90 | RAB9A (0.32) | HDAC1HDAC3HDAC2HDAC6AKR1C3 | |
| Hydrochloric Acid SCHEMBL5172809 | 0.90 | HDAC1 (0.36) | HDAC1KCNH2HDAC3HDAC2HDAC6 | |
| SCHEMBL5171686 | 0.89 | SLC6A2 (0.35) | SLC6A2SLC6A3CYP2D6AKR1C3AKR1C2 | |
| SCHEMBL5169656 | 0.88 | HDAC1 (0.40) | HDAC1AKR1C3AKR1C4AKR1C2MEN1 | |
| SCHEMBL5197780 | 0.85 | HDAC3 (0.38) | SLC6A2SLC6A4SLC6A3HDAC1CYP2D6 | |
| SCHEMBL5171832 | 0.85 | RAB9A (0.31) | HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL5171617 | 0.85 | SLC6A2 (0.34) | SLC6A2SLC6A3HDAC1HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776357-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | Astellas Pharma Inc. (JP) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006016680-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | ASTELLAS PHARMA INC. (JP) | 2006-02-16 | — | — | WO | disclosed |