Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5195209 | 0.94 | SLC6A2 (0.32) | SLC6A2SLC6A4SLC6A3HDAC1HDAC3 | |
| SCHEMBL5197780 | 0.91 | HDAC3 (0.38) | SLC6A2SLC6A4SLC6A3HDAC1RAB9A | |
| SCHEMBL5167688 | 0.91 | AKR1C3 (0.32) | SLC6A4HDAC1ALDH1A1ADRB2HTT | |
| SCHEMBL5171832 | 0.91 | RAB9A (0.31) | HDAC1NPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL5191421 | 0.85 | HDAC3 (0.39) | SLC6A2SLC6A4SLC6A3HDAC1RAB9A | |
| SCHEMBL5170345 | 0.85 | — | — | |
| SCHEMBL5195227 | 0.85 | RAB9A (0.32) | HDAC1NPC1RAB9ASMN1; SMN2HDAC3 | |
| SCHEMBL5170237 | 0.85 | AKR1C3 (0.33) | HDAC1SMN1; SMN2ALDH1A1HDAC3HDAC2 | |
| Hydrochloric Acid SCHEMBL5172809 | 0.84 | HDAC1 (0.36) | HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL5169133 | 0.84 | ALDH1A1 (0.35) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776357-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | Astellas Pharma Inc. (JP) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006016680-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | ASTELLAS PHARMA INC. (JP) | 2006-02-16 | — | — | WO | disclosed |