SCHEMBL5169749

SCHEMBL5169749

O=C(NC(=O)N1CCC(Cc2ccccc2)CC1)c1ccc(NC(=O)c2ccccc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FAAH O00519 4/20 0.67
KMT2A Q03164 3/20 0.60
MEN1 O00255 2/20 0.60
SMN1; SMN2 Q16637 1/20 0.60
POLB P06746 3/20 0.59
MAPT P10636 1/20 0.59
NPSR1 Q6W5P4 1/20 0.59
GRIN2D O15399 1/20 0.57
GRIN3B O60391 1/20 0.57
GRIN1 Q05586 1/20 0.57
GRIN2A Q12879 1/20 0.57
GRIN2B Q13224 1/20 0.57
GRIN2C Q14957 1/20 0.57
GRIN3A Q8TCU5 1/20 0.57
CHRM2 P08172 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5284883 0.93 FAAH (0.62) FAAHKMT2AMEN1SMN1; SMN2POLB
SCHEMBL5180412 0.91 FAAH (0.65) FAAHKMT2AMEN1SMN1; SMN2POLB
SCHEMBL4239616 0.87 FAAH (0.61) FAAHKMT2AMEN1POLBGRIN2D
SCHEMBL5165726 0.86 FAAH (0.60) FAAHKMT2AMEN1POLB
SCHEMBL4244727 0.84 FAAH (0.56) FAAHKMT2AMEN1SMN1; SMN2POLB
SCHEMBL5170570 0.82 HTT (0.73) FAAHKMT2AMEN1SMN1; SMN2POLB
SCHEMBL4246343 0.82 MEN1 (0.55) FAAHKMT2AMEN1SMN1; SMN2POLB
SCHEMBL3600315 0.81 FAAH (1.00) FAAHKMT2AMEN1SMN1; SMN2POLB
SCHEMBL4245364 0.80 CCR3 (0.53) FAAHKMT2AMEN1SMN1; SMN2POLB
SCHEMBL24398131 0.79 FAAH (0.60) FAAHKMT2AMEN1SMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1771429-A1 NEW BENZOYL UREA DERIVATIVES RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2007-04-11 EP disclosed
WO-2006010966-A1 NEW BENZOYL UREA DERIVATIVES Richter Gedeon Vegyészeti Gyár Rt. (HU) 2006-02-02 WO disclosed