SCHEMBL4245364

SCHEMBL4245364

CC(=O)Nc1ccc(C(=O)NC(=O)N2CCC(Cc3ccc(F)cc3)CC2)cc1

nearest known ligand 0.59

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CCR3 P51677 3/20 0.53
KMT2A Q03164 3/20 0.53
POLB P06746 1/20 0.53
MAPT P10636 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
FAAH O00519 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.50
MEN1 O00255 1/20 0.48
GRIN1 Q05586 2/20 0.47
GRIN2B Q13224 2/20 0.47
GRIN2D O15399 1/20 0.47
GRIN3B O60391 1/20 0.47
GRIN2A Q12879 1/20 0.47
GRIN2C Q14957 1/20 0.47
GRIN3A Q8TCU5 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5180412 0.89 FAAH (0.65) KMT2APOLBMAPTNPSR1FAAH
SCHEMBL4243146 0.85 CCR3 (0.49) CCR3KMT2AMEN1GRIN1GRIN2B
SCHEMBL4245365 0.82 POLB (0.54) CCR3KMT2APOLBMAPTNPSR1
SCHEMBL5169749 0.80 FAAH (0.67) KMT2APOLBMAPTNPSR1FAAH
SCHEMBL4577175 0.78 SMN1; SMN2 (0.59) CCR3KMT2ASMN1; SMN2MEN1
SCHEMBL5284883 0.77 FAAH (0.62) KMT2APOLBMAPTNPSR1FAAH
SCHEMBL4243510 0.77 FAAH (0.56) KMT2APOLBMAPTFAAHMEN1
SCHEMBL14559864 0.76 MEN1 (0.56) CCR3KMT2APOLBMAPTMEN1
SCHEMBL7238932 0.75 POLB (0.68) KMT2APOLBMAPTNPSR1FAAH
SCHEMBL4252214 0.75 KMT2A (0.47) KMT2APOLBFAAHSMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090170901-A1 Benzoyl Urea Derivatives RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2009-07-02 US disclosed
EP-1771429-A1 NEW BENZOYL UREA DERIVATIVES RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 2007-04-11 EP disclosed
WO-2006010966-A1 NEW BENZOYL UREA DERIVATIVES Richter Gedeon Vegyészeti Gyár Rt. (HU) 2006-02-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090170901-A1 Benzoyl Urea Derivatives OPRM1, GRIN2C, GRIN3A CCR3 1472/4885KMT2A 3249/4885POLB 2381/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.