Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | NNMT | P40261 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5431919 | 0.84 | KDM4E (0.55) | TDP1KDM4EL3MBTL1KMT2AP2RX7 | |
| SCHEMBL30590435 | 0.84 | SMN1; SMN2 (0.42) | PIK3CBLIMK1KDM4EKMT2AMKNK1 | |
| SCHEMBL353138 | 0.82 | SIRT3 (0.46) | SIRT3TDP1PIK3CBLIMK1KDM4E | |
| Hydrochloric Acid SCHEMBL5796678 | 0.80 | SIRT3 (0.44) | SIRT3TDP1PIK3CBLIMK1KDM4E | |
| SCHEMBL9002808 | 0.80 | SIRT3 (0.44) | SIRT3TDP1PIK3CBKDM4EL3MBTL1 | |
| SCHEMBL38666595 | 0.79 | KDM4E (0.53) | KDM4EP2RX7MAPTALDH1A1 | |
| SCHEMBL17545204 | 0.79 | KDM4E (0.53) | KDM4EP2RX7MAPTALDH1A1 | |
| SCHEMBL21248760 | 0.79 | NOS3 (0.45) | SIRT3TDP1PIK3CBLIMK1KDM4E | |
| SCHEMBL17195496 | 0.78 | MKNK1 (0.44) | SIRT3TDP1PIK3CBKDM4EL3MBTL1 | |
| SCHEMBL18426275 | 0.77 | SIRT3 (0.50) | SIRT3TDP1PIK3CBLIMK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021086879-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2021-05-06 | — | — | WO | disclosed |
| EP-1697308-A4 | PHENYLAMIDE AND PYRIDYLAMIDE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER S DISEASE | MERCK & CO INC (US) | 2007-08-22 | — | — | EP | disclosed |
| EP-1697308-A2 | PHENYLAMIDE AND PYRIDYLAMIDE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER S DISEASE | Merck & Co., Inc. (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005065195-A2 | PHENYLAMIDE AND PYRIDYLAMIDE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2005-07-21 | — | — | WO | disclosed |