Kio-100

Kio-100

SCHEMBL517019

O=C(Nc1c(F)c(F)c(-c2cccc(OC(F)(F)F)c2)c(F)c1F)c1ccsc1C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 18/20 1.00
DHFR P00374 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18624759 0.92 DHODH (0.85) DHODHDHFR
SCHEMBL18624760 0.92 DHODH (0.85) DHODHDHFR
SCHEMBL18118634 0.89 DHODH (0.80) DHODHDHFR
SCHEMBL26244623 0.88 DHODH (0.78) DHODHDHFR
SCHEMBL517805 0.87 DHODH (1.00) DHODH
SCHEMBL24180479 0.84 DHODH (0.71) DHODHDHFR
Kio-100 SCHEMBL29869083 0.83 DHODH (0.72) DHODHDHFR
SCHEMBL30693925 0.81 DHODH (0.68) DHODHDHFR
SCHEMBL299933 0.79 DHODH (1.00) DHODHDHFR
SCHEMBL26244615 0.78 DHODH (0.64) DHODHDHFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12472263-B2 Ophthalmic formulation PANOPTES PHARMA GES.M.B.H (AT) 2025-11-18 US claimed
US-12209073-B2 Polymorphs of a dihydroorotate dehydrogenase (DHOD) inhibitor KIORA PHARMACEUTICALS GMBH (AT) 2025-01-28 US claimed
CN-119300819-A Polymorphs of a dihydroorotate dehydrogenase (DHOD) inhibitor 克奥拉制药股份有限公司 2025-01-10 CN claimed
EP-3761960-B1 OPHTHALMIC FORMULATION KIORA PHARMACEUTICALS GMBH (DE) 2023-11-22 EP claimed
US-20230286938-A1 POLYMORPHS OF A DIHYDROOROTATE DEHYDROGENASE (DHOD) INHIBITOR PANOPTES PHARMA GMBH (AT) 2023-09-14 US claimed
WO-2023172818-A1 POLYMORPHS OF A DIHYDROOROTATE DEHYDROGENASE (DHOD) INHIBITOR KIORA PHARMACEUTICALS GMBH (AT) 2023-09-14 WO claimed
US-11730716-B2 Compounds for treating ophthalmic diseases and disorders KIORA PHARMACEUTICALS GMBH (AT) 2023-08-22 US claimed
CN-111163757-B Ophthalmic preparation 帕诺泰斯制药有限公司 2022-04-19 CN claimed
EP-2427186-B1 DIHYDROOROTATE-DEHYDROGENASEE INHIBITORS AS VIROSTATIC COMPOUNDS PANOPTES PHARMA GES M B H (AT) 2022-01-12 EP claimed
US-20210052737-A1 OPHTHALMIC FORMULATION PANOPTES PHARMA GES.M.B.H (AT) 2021-02-25 US claimed
EP-3761960-A1 OPHTHALMIC FORMULATION Panoptes Pharma GmbH (AT) 2021-01-13 EP claimed
CN-111163757-A Ophthalmic preparation 帕诺泰斯制药有限公司 2020-05-15 CN claimed
WO-2019170848-A1 OPHTHALMIC FORMULATION PANOPTES PHARMA GES.M.B.H. (AT) 2019-09-12 WO claimed
US-9795590-B2 Anti-inflammatory agents as virostatic compounds PANOPTES PHARMA GMBH (AT) 2017-10-24 US claimed
US-20170071904-A1 COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS KIORA PHARMACEUTICALS GMBH (AT) 2017-03-16 US claimed
US-20170027905-A1 ANTI-INFLAMMATORY AGENTS AS VIROSTATIC COMPOUNDS Panoptes Hparma GmbH (AT) 2017-02-02 US claimed
WO-2015154820-A1 ANTI-INFLAMMATORY AGENTS AS VIROSTATIC COMPOUNDS PANOPTES PHARMA GMBH (AT) 2015-10-15 WO claimed
US-8354433-B2 Anti-inflammatory agents as virostatic compounds 4SC AG (DE) 2013-01-15 US claimed
US-20250381167-A1 COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS KIORA PHARMACEUTICALS GMBH (AT) 2025-12-18 US disclosed
WO-2004056797-A1 AROMATIC COMPOUNDS AS ANTI-INFLAMMATORY, IMMUNOMODULATORY AND ANTI-PROLIFERATORY AGENTS 4SC AG (DE) 2004-07-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12209073-B2 Polymorphs of a dihydroorotate dehydrogenase (DHOD) inhibitor DHODH, DPYD, DLD DHODH 1/4885DHFR 8/4885
US-20230286938-A1 POLYMORPHS OF A DIHYDROOROTATE DEHYDROGENASE (DHOD) INHIBITOR DHODH, DPYD, DLD DHODH 1/4885DHFR 8/4885
US-20170071904-A1 COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS DHODH, ALDH1A2, QDPR DHODH 1/4885DHFR 38/4885
US-11730716-B2 Compounds for treating ophthalmic diseases and disorders DHODH, ALDH1A2, QDPR DHODH 1/4885DHFR 38/4885
US-20250381167-A1 COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS DHODH, ALDH1A2, QDPR DHODH 1/4885DHFR 38/4885
US-20170027905-A1 ANTI-INFLAMMATORY AGENTS AS VIROSTATIC COMPOUNDS TNF, RPL35, NFKBIA DHODH 2832/4885DHFR 3370/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.