Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.33 |
| ▸ | PARP1 | P09874 | 3/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | SMO | Q99835 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5171053 | 0.92 | HRH3 (0.35) | HRH3NAMPTPARP1KDM4CBRD4 | |
| SCHEMBL5183241 | 0.89 | HRH3 (0.33) | HRH3KDM4C | |
| SCHEMBL5170766 | 0.88 | SMO (0.34) | HRH3KDM4CSMO | |
| SCHEMBL5170240 | 0.86 | HRH3 (0.35) | HRH3NAMPTMAP3K5PARP1HDAC3 | |
| SCHEMBL5170769 | 0.85 | SLC18A2 (0.33) | KDM4C | |
| SCHEMBL5183100 | 0.85 | ACACB (0.32) | NAMPTCHEK1 | |
| SCHEMBL5169168 | 0.82 | PRMT5 (0.37) | HRH3NAMPT | |
| SCHEMBL5173434 | 0.82 | KDM4C (0.35) | PARP1KDM4C | |
| SCHEMBL5171939 | 0.81 | HRH3 (0.40) | HRH3HDAC3HDAC1HDAC2 | |
| SCHEMBL5170218 | 0.80 | DEGS1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |