Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | UBE2M | P61081 | 2/20 | 0.44 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5170387 | 0.87 | MEN1 (0.51) | ALDH1A1KDM4EATMNPSR1KMT2A | |
| SCHEMBL1307812 | 0.85 | OPRM1 (0.55) | ALDH1A1KDM4EACHECHRM2CHRM3 | |
| SCHEMBL1921304 | 0.80 | SIGMAR1 (0.53) | ALDH1A1KDM4EATMKMT2ADCUN1D1 | |
| SCHEMBL5171694 | 0.78 | OPRM1 (0.57) | CHRM1CHRM3DRD4 | |
| SCHEMBL20544083 | 0.78 | KDM4E (0.55) | ALDH1A1KDM4EKMT2AACHESMN1; SMN2 | |
| SCHEMBL20544081 | 0.78 | KDM4E (0.55) | ALDH1A1KDM4EKMT2AACHESMN1; SMN2 | |
| SCHEMBL1306000 | 0.77 | OPRM1 (0.61) | ACHECHRM2CHRM3 | |
| SCHEMBL10367448 | 0.77 | OPRM1 (0.49) | KMT2AACHECHRM2CHRM3MEN1 | |
| SCHEMBL1306321 | 0.75 | SMN1; SMN2 (0.39) | SMN1; SMN2CHRM2CHRM1CHRM3CYP3A4 | |
| SCHEMBL2549060 | 0.75 | SMN1; SMN2 (0.39) | SMN1; SMN2CHRM2CHRM1CHRM3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776357-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | Astellas Pharma Inc. (JP) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006016680-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | ASTELLAS PHARMA INC. (JP) | 2006-02-16 | — | — | WO | disclosed |