Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1921304 | 0.93 | SIGMAR1 (0.53) | MEN1KMT2AALDH1A1MAPK1SIGMAR1 | |
| SCHEMBL5170792 | 0.87 | ALDH1A1 (0.52) | MEN1KMT2AALDH1A1NPSR1ATM | |
| SCHEMBL1307812 | 0.84 | OPRM1 (0.55) | ALDH1A1SIGMAR1KDM4E | |
| SCHEMBL20544083 | 0.77 | KDM4E (0.55) | MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL20544081 | 0.77 | KDM4E (0.55) | MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL5171694 | 0.77 | OPRM1 (0.57) | SIGMAR1 | |
| SCHEMBL1306000 | 0.76 | OPRM1 (0.61) | SIGMAR1 | |
| SCHEMBL19652134 | 0.76 | CCR5 (0.52) | MEN1KMT2AALDH1A1MAPK1SIGMAR1 | |
| SCHEMBL10367448 | 0.76 | OPRM1 (0.49) | MEN1KMT2ASIGMAR1 | |
| SCHEMBL17076150 | 0.76 | MEN1 (0.52) | MEN1KMT2AALDH1A1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776357-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | Astellas Pharma Inc. (JP) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006016680-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | ASTELLAS PHARMA INC. (JP) | 2006-02-16 | — | — | WO | disclosed |