Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5172609 | 0.92 | GCK (0.42) | AKR1C3KDM4EALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL5197786 | 0.89 | SLC6A2 (0.36) | CYP2D6SLC6A2SLC6A4SLC6A3CA2 | |
| SCHEMBL5197021 | 0.88 | AKR1C3 (0.34) | AKR1C3AKR1C2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL5191421 | 0.87 | HDAC3 (0.39) | CYP2D6SLC6A2SLC6A4SLC6A3HDAC3 | |
| SCHEMBL5171686 | 0.87 | SLC6A2 (0.35) | AKR1C3AKR1C2CYP2D6SLC6A2SLC6A3 | |
| SCHEMBL5171643 | 0.86 | HDAC4 (0.34) | CYP2D6SLC6A2SLC6A4SLC6A3HDAC1 | |
| SCHEMBL5170203 | 0.86 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3LMNAHDAC4 | |
| SCHEMBL5168837 | 0.84 | TYRO3 (0.36) | CYP2D6ALDH1A1 | |
| SCHEMBL5170237 | 0.83 | AKR1C3 (0.33) | AKR1C3AKR1C2HDAC3HDAC1HDAC2 | |
| SCHEMBL5172054 | 0.82 | TGFBR1 (0.35) | CYP2D6SLC6A2SLC6A4SLC6A3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776357-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | Astellas Pharma Inc. (JP) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006016680-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | ASTELLAS PHARMA INC. (JP) | 2006-02-16 | — | — | WO | disclosed |