Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 15/20 | 0.33 |
| ▸ | AKR1C4 | P17516 | 10/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 10/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5167688 | 0.94 | AKR1C3 (0.32) | AKR1C3AKR1C4AKR1C2AKR1C1LMNA | |
| SCHEMBL5191421 | 0.91 | HDAC3 (0.39) | LMNAHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL5172911 | 0.90 | HDAC1 (0.37) | LMNAHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL5195227 | 0.90 | RAB9A (0.32) | AKR1C3AKR1C4AKR1C2LMNAHDAC3 | |
| SCHEMBL5195209 | 0.90 | SLC6A2 (0.32) | AKR1C3AKR1C4AKR1C2HDAC3HDAC1 | |
| SCHEMBL5197786 | 0.90 | SLC6A2 (0.36) | LMNAHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL5197780 | 0.85 | HDAC3 (0.38) | LMNAHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL5171832 | 0.85 | RAB9A (0.31) | LMNAHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL5169616 | 0.85 | MAPKAPK2 (0.31) | HDAC3HDAC1HDAC2HDAC6ALDH1A1 | |
| SCHEMBL5172395 | 0.85 | GAA (0.35) | HDAC3HDAC1HDAC2HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776357-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | Astellas Pharma Inc. (JP) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006016680-A1 | HYDROXYAMIDE COMPOUNDS HAVING ACTIVITY AS INHIBITORS OF HISTONE DEACETYLASE (HDAC) | ASTELLAS PHARMA INC. (JP) | 2006-02-16 | — | — | WO | disclosed |