Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACP1 | P24666 | 2/20 | 0.33 |
| ▸ | FBP1 | P09467 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzenesulfonamide SCHEMBL28080436 | 0.83 | CA12 (0.46) | ALDH1A1CA12CA2HSD17B10MEN1 | |
| SCHEMBL27809409 | 0.83 | ALDH1A1 (0.37) | ALDH1A1TSHRNOS1HSD17B10PKM | |
| SCHEMBL27681940 | 0.80 | CA12 (0.39) | ALDH1A1CA12CA2TSHRNOS1 | |
| SCHEMBL3165386 | 0.79 | ALDH1A1 (0.39) | ALDH1A1CA12CA2TSHRNOS1 | |
| SCHEMBL2591217 | 0.78 | ALDH1A1 (0.38) | ALDH1A1CA12CA2TSHRNOS1 | |
| SCHEMBL7251604 | 0.73 | CA12 (0.46) | ALDH1A1CA12CA2HSD17B10MEN1 | |
| SCHEMBL28170599 | 0.73 | SCN9A (0.32) | ALDH1A1TSHRNOS1HSD17B10SCN9A | |
| SCHEMBL28617469 | 0.73 | ALDH1A1 (0.34) | ALDH1A1TSHRNOS1HSD17B10SCN9A | |
| SCHEMBL3964499 | 0.72 | MEN1 (0.40) | ALDH1A1CA2MEN1KMT2ASCN9A | |
| SCHEMBL30999657 | 0.72 | METAP2 (0.45) | ALDH1A1CA12CA2HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4845219-A | ANTITUMOR, ANTOCOAGULANT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-07-04 | — | — | US | claimed |
| EP-0255366-A2 | Nitrogen- and sulfur-containing lipid compound, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1988-02-03 | — | — | EP | claimed |
| EP-1778250-A2 | NOVEL THIAZOLE INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE | Metabasis Therapeutics, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006023515-A2 | NOVEL THIAZOLE INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE | METABASIS THERAPEUTICS, INC. (US) | 2006-03-02 | — | — | WO | disclosed |
| CN-1050191-A | New thiazole derivative, they the preparation method and contain their pharmaceutical composition | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-03-27 | — | — | CN | disclosed |
| CN-1043936-A | Thiazolium compounds and preparation method thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1990-07-18 | — | — | CN | disclosed |
| CN-1040796-A | The preparation method of fruylthiazole derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1990-03-28 | — | — | CN | disclosed |